236394-37-9

236394-37-9 structure

Name: sPLA2-IIA Inhibitor
Chemical Name: sPLA2-IIA Inhibitor
CAS Number: 236394-37-9
Molecular Formula: C₄₁H₅₀N₈O₆
Molecular Weight: 750.89
Catalog: Research Areas Metabolic Disease
Create Date: 2024-02-23 00:45:50
Modify Date: 2025-12-27 00:26:24
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids[1].

Name	sPLA2-IIA Inhibitor

Description	sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Kim RR, et al. Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human Group IIA phospholipase A2. Proteins. 2017;85(5):827-842. doi:10.1002/prot.25235

Molecular Formula	C₄₁H₅₀N₈O₆
Molecular Weight	750.89