51-12-7

51-12-7 structure

Name: Nialamide
Chemical Name: N-benzyl-3-[2-(pyridine-4-carbonyl)hydrazinyl]propanamide
CAS Number: 51-12-7
Molecular Formula: C₁₆H₁₈N₄O₂
Molecular Weight: 298.34000
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-10-04 17:07:27
Modify Date: 2024-01-11 02:00:27
Nialamide is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant.

Name	N-benzyl-3-[2-(pyridine-4-carbonyl)hydrazinyl]propanamide
Synonyms	4-pyridinecarboxylic acid Nialamid N-[2-(benzylcarbamoyl)ethyl]-N'-isonicotinyl hydrazide N-benzyl-3-(N'-(pyridine-4-carbonyl)hydrazino)propanamide EINECS 200-079-3 Niamidal Niamid Psicodisten MFCD00010106 2-{3-oxo-3-[(phenylmethyl)amino]propyl}hydrazide Novazid Niazin Nuredal Nyazin N-benzyl-3-(N'-isonicotinoyl-hydrazino)-propionamide Niaquitil Nialamide

Description	Nialamide is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease

Density	1.203g/cm3
Boiling Point	538.1ºC at 760mmHg
Melting Point	152-154ºC(lit.)
Molecular Formula	C₁₆H₁₈N₄O₂
Molecular Weight	298.34000
Flash Point	279.2ºC
Exact Mass	298.14300
PSA	83.12000
LogP	2.19520
Index of Refraction	1.589
Water Solubility	ethanol: clear to hazy

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS1225000

CHEMICAL NAME :: Isonicotinic acid, 2-(2-(benzylcarbamoyl)ethyl)hydrazide

CAS REGISTRY NUMBER :: 51-12-7

BEILSTEIN REFERENCE NO. :: 0492941

LAST UPDATED :: 199612

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C16-H18-N4-O2

MOLECULAR WEIGHT :: 298.38

WISWESSER LINE NOTATION :: T6NJ DVMM2VM1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 54600 mg/kg/26W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 24 mg/kg

SEX/DURATION :: female 1-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: DNA damage

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 435 mg/kg

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,287,1982 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 2,209,1975 TOXICOLOGY REVIEW HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302 + H312 + H332-H315-H319-H335-H351
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	20/21/22-36/37/38-40
Safety Phrases	S22;S26;S36
RIDADR	UN 3249
WGK Germany	3
RTECS	NS1225000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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