135646-98-9

135646-98-9 structure

Name: 15-Keto latanoprost
Chemical Name: propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]hept-5-enoate
CAS Number: 135646-98-9
Molecular Formula: C₂₆H₃₈O₅
Molecular Weight: 430.58
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2016-01-15 10:45:34
Modify Date: 2024-01-12 13:39:46
15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent[1].

Name	propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]hept-5-enoate
Synonyms	(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoate 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-, 1-methylethyl ester, (5Z)- 15-Ketolatanoprost (5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]cyclopentyl}-5-heptenoic acid [1R-[1\|A(Z),2\|A,3\|A,5\|A]]-7-[3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]cyclopentyl]-, (5Z)-

Description	15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
In Vivo	In cynomolgus monkeys, the acid of Latanoprost had a short half-life in plasma and it is partly converted to the 15-keto acid of latanoprost. β-Oxidation of the acid of latanoprost was the major metabolic pathway[1].
References	[1]. B Sjöquist, et al. Pharmacokinetics of latanoprost in the cynomolgus monkey. 2nd communication: repeated topical administration on the eye. Arzneimittelforschung. 1999 Mar;49(3):234-9.