135646-98-9

• 常用中文名：15-Keto latanoprost
• 常用英文名：15-Keto latanoprost
• CAS号：135646-98-9
• 分子式：C₂₆H₃₈O₅
• 分子量：430.58
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 前列腺素受体
• 发布时间：2016-01-15 10:45:34
• 更新时间：2026-08-03 18:55:30
• 15酮拉坦前列素是拉坦前列素的代谢产物,拉坦前列素是一种降眼压剂[1]。

名称

• 中文名: 15-氧代拉坦前列素
• 英文名: propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]hept-5-enoate
• 中文别名: 15-酮拉坦前列素; 拉坦前列腺素杂质13; 拉坦前列素杂质13
• 英文别名: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester; Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoate; 9ALPHA,11ALPHA-DIHYDROXY-15-OXO-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID ISOPROPYL ESTER; 15-Keto Latanoprost Impurity; 15-Ketolatanoprost; propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]ht-5-enoate; (5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]cyclopentyl}-5-heptenoic acid; 15-Keto Latanoprost/(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-htenoic Acid 1-Methylethyl Ester; 15-KETO LATANOPROST; [1R-[1α(Z),2β,3α,5α]]-7-[3,5-Dihydroxy-2-(3-oxo- 5-phenylpentyl)cyclopentyl]-5-htenoic Acid 1-Methylethyl Ester; Latanoprost Impurity 5; 5-Htenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-, 1-methylethyl ester, (5Z); (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-htenoic Acid 1-Methylethyl Ester; Latanoprost Impurity 13; 15-ketolatanprost; [1R-[1|A(Z),2|A,3|A,5|A]]-7-[3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester; isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl)ht- 5-enoate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 594.2±50.0 °C at 760 mmHg
• 分子式: C₂₆H₃₈O₅
• 分子量: 430.58
• 闪点: 327.2±26.6 °C
• 精确质量: 386.209320
• PSA: 83.83000
• LogP: 1.90
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.608

生物活性

• 描述: 15酮拉坦前列素是拉坦前列素的代谢产物,拉坦前列素是一种降眼压剂[1]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
• 体内研究: 在食蟹猴体内,拉坦前列素的酸在血浆中的半衰期很短,部分转化为拉坦前列素的15-酮酸。拉坦前列素酸的β-氧化是主要代谢途径[1]。
• 参考文献:

  [1]. B Sjöquist, et al. Pharmacokinetics of latanoprost in the cynomolgus monkey. 2nd communication: repeated topical administration on the eye. Arzneimittelforschung. 1999 Mar;49(3):234-9.