145774-33-0

145774-33-0 structure

Name: C8 dihydro Ceramide (d18:0/8:0)
Chemical Name: N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]octanamide
CAS Number: 145774-33-0
Molecular Formula: C₂₆H₅₃NO₃
Molecular Weight: 427.70400
Catalog: Research Areas Cancer
Create Date: 2017-02-28 01:38:17
Modify Date: 2024-01-04 12:29:20
C8 Dihydroceramide is a negative control of C8 Ceramide. C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro[1][2][3][4].

Name	N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]octanamide
Synonyms	C8 dihydrosphingosine N-08:0 Sphinganine C8 Sphinganine C8 dihydrosphingosine N-(octanoyl)-sphinganine N-08:0 Sphinganine C8 DIHYDROCERAMIDE C8 Sphinganine

Description	C8 Dihydroceramide is a negative control of C8 Ceramide. C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	C8-dihydro-ceramide had no effect on cell viability in any of the cell lines tested[5].
References	[1]. Rebeca López-Marure , et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36. [2]. Yuli C. Chang, et al. Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018 Oct; 19(10): 3010. [3]. H W Huang, et al. Ceramides modulate protein kinase C activity and perturb the structure of Phosphatidylcholine/Phosphatidylserine bilayers. Biophys J. 1999 Sep; 77(3): 1489-1497. [4]. Lan Weiss, et al. Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy. Hum Mol Genet. 2021 Jan 7;ddaa248. [5]. Rebeca López-Marure, et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36.

Molecular Formula	C₂₆H₅₃NO₃
Molecular Weight	427.70400
Exact Mass	427.40300
PSA	73.05000
LogP	7.50650
Storage condition	-20°C

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