Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-nitrosodiethanolamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

1116-54-7

1116-54-7 structure

Name: 2,2'-(Nitrosoimino)diethanol
Chemical Name: N,N-bis(2-hydroxyethyl)nitrous amide
CAS Number: 1116-54-7
Molecular Formula: C₄H₁₀N₂O₃
Molecular Weight: 134.134
Catalog: analytical chemistry Standard Cosmetic standard
Create Date: 2018-07-30 15:47:19
Modify Date: 2026-07-05 13:48:42

Name	N,N-bis(2-hydroxyethyl)nitrous amide
Synonyms	diaethanolnitrosamin DIETHANOLNITROSAMINE N-DIETHANOLNITROSAMINE rcrawastenumberu173 N-Nitroso Trazodone Impurity 12 EINECS 214-237-4 Nitrosobis(2-hydroxyethyl)amine 2,2'-nitrosiminodiethanol Morinidazole Impurity 34 N-Nitrosodiethanolamine(NDELA) 2,2’-(nitrosoimino)bis-ethano N-Nitrosodiethanolamine di-(2-hydroxyethyl)-nitrosamine ndela n-nitrosobis(2-hydroxyethyl)amine bis-2-hydroxy-ethyl-nitroso-amine diethanolnitrosoamine N-Nitroso-diethanolamine 100 μg/mL in Methanol Diethanolnitrosoamine bis(beta-hydroxyaethyl)nitrosamin N-nitroso-diethanolamine NDELA 3,7 n-nitrosoiminodi-ethano 2,2’-iminodi-n-nitrosoethanol N-Nitroso-diethanolamine Solution in Methanol, 1000μg/mL bis(beta-hydroxyethyl)nitrosamine nci-c55583 Nitrosodiethanolamine Ethanol, 2,2-(nitrosoimino)bis Ethanol,2,2'-nitrosiminodi N-Nitrosodiethanolamine> Di-(2-hydroxyethyl)nitrosamine n-nitrosodiaethanolamin nitrosoiminodiethanol diaethanolnitrosamin (german) 2-[(2-hydroxyethyl)(nitroso)amino]ethan-1-ol 2,2'-dihydroxy-N-nitrosodiethylamine Bis(2-hydroxyethyl)nitrosamine Nitrosoimino diethanol n,n-diethanolnitrosamine bis(beta-hydroxyaethyl)nitrosamin (german) Trolamine Impurity C N,N-Diethanolnitrosamine ETHANOL,N-NITROSOIMINODI N-Nitrosodiethanolamine N-nitrosoiminodiethanol 2,2′-(nitrosoimino)diethanol (N-nitrosodiethanolamine) 2,2'-(Nitrosoimino)diethanol (N-Nitrosodiethanolamine) 2,2’-nitrosiminodi-ethano n-nitrosoaminodiethanol N-Nitrosoamindiethanol MFCD00015522 2,2’-dihydroxy-n-nitroso-diethylamin N-NITROSODIETHANOLAMINE 2,2’-(nitrosoimino)bisethanol nitrosodiethanolamine bis-(2-hydroxy-ethyl)-nitroso-amine n-Nitroso-bis(2-hydroxymethyl)-amine Diethanolnitrosamine N-Nitrosoaminodiethanol Ndela 2,2’-(nitrosoimino)bis-Ethanol

Density	1.3±0.1 g/cm3
Boiling Point	375.9±27.0 °C at 760 mmHg
Molecular Formula	C₄H₁₀N₂O₃
Molecular Weight	134.134
Flash Point	181.1±23.7 °C
Exact Mass	134.069138
PSA	73.13000
LogP	-1.89
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.499
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KL9550000

CHEMICAL NAME :: Ethanol, N-nitrosoiminodi-

CAS REGISTRY NUMBER :: 1116-54-7

BEILSTEIN REFERENCE NO. :: 1762620

LAST UPDATED :: 199710

DATA ITEMS CITED :: 42

MOLECULAR FORMULA :: C4-H10-N2-O3

MOLECULAR WEIGHT :: 134.16

WISWESSER LINE NOTATION :: Q2NNO&&2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 855 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 295 mg/kg/10W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 21600 mg/kg/36W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 6080 mg/kg/27W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 21600 mg/kg/45W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 7200 mg/kg/27W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/50W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg/75W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3450 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg/50W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 10500 mg/kg/42W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 gm/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 17920 mg/kg/27W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 15 gm/kg/5W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1202 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA damage

MUTATION DATA

TYPE OF TEST :: Host-mediated assay

TEST SYSTEM :: Rodent - mouse Bacteria - Escherichia coli

DOSE/DURATION :: 450 umol/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 2,909,1981 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 17,77,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 17,77,1978 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993

Symbol	GHS02, GHS08
Signal Word	Danger
Hazard Statements	H225-H350
Precautionary Statements	P201-P210-P308 + P313
Hazard Codes	T
Risk Phrases	R45:May cause cancer.
Safety Phrases	S53-S45
RIDADR	UN 1993 3/PG 2
WGK Germany	1
RTECS	KL9550000
Packaging Group	II
Hazard Class	3.1
HS Code	2928000090

111-42-2

~98%

1116-54-7

Literature: Zolfigol, Mohammad Ali; Bamoniri, Abdolhamid Synlett, 2002 , # 10 p. 1621 - 1624

102699-37-6

1116-54-7

102699-41-2

Literature: Journal of Organic Chemistry, , vol. 51, # 14 p. 2687 - 2694

102699-34-3

1116-54-7

80324-65-8

Literature: Journal of Organic Chemistry, , vol. 51, # 14 p. 2687 - 2694

102-71-6

~59%

1116-54-7

Literature: Zhang, Jie; Jiang, Jiewen; Li, Yuling; Wan, Xiaobing Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11366 - 11372

563-70-2

111-42-2

50-00-0

1116-54-7

Literature: Journal of the Chemical Society, Chemical Communications, , # 22 p. 1598 - 1599

134469-02-6

111-42-2

1116-54-7

Literature: Toxicology, , vol. 163, # 2-3 p. 127 - 136

56577-02-7

111-42-2

1116-54-7

Literature: Toxicology, , vol. 163, # 2-3 p. 127 - 136

57564-91-7

111-42-2

1116-54-7

Literature: Toxicology, , vol. 163, # 2-3 p. 127 - 136

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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