CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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AH1350000
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CHEMICAL NAME :
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Acetic acid, ester with 2,6-dimethyl-m-dioxan-4-ol
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CAS REGISTRY NUMBER :
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828-00-2
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BEILSTEIN REFERENCE NO. :
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0128710
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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22
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MOLECULAR FORMULA :
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C8-H14-O4
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MOLECULAR WEIGHT :
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174.22
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WISWESSER LINE NOTATION :
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T6O COTJ B1 DOV1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1930 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2800 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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12 gm/kg/16D-I
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TOXIC EFFECTS :
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Gastrointestinal - other changes Liver - changes in liver weight
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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32500 mg/kg/13W-I
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TOXIC EFFECTS :
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Brain and Coverings - changes in brain weight Gastrointestinal - other changes Kidney, Ureter, Bladder - changes in bladder weight
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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24 gm/kg/16D-I
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TOXIC EFFECTS :
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Gastrointestinal - other changes Liver - changes in liver weight Related to Chronic Data - death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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948 gm/kg/88W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - leukemia
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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25750 mg/kg/2Y-C
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
MUTATION DATA
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TYPE OF TEST :
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Sister chromatid exchange
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TEST SYSTEM :
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Rodent - hamster Ovary
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DOSE/DURATION :
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3660 ug/L
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-354,1989 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,177,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,177,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83665 No. of Facilities: 76 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 491 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83665 No. of Facilities: 11278 (estimated) No. of Industries: 114 No. of Occupations: 90 No. of Employees: 183978 (estimated) No. of Female Employees: 80381 (estimated)
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