Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: o-toluidine hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

636-21-5

636-21-5 structure

Name: o-Toluidine HCl
Chemical Name: 2-methylaniline,hydrochloride
CAS Number: 636-21-5
Molecular Formula: C₇H₁₀ClN
Molecular Weight: 143.614
Catalog: Organic raw materials Amino compound Acyclic monoamines, polyamines and their derivatives and salts
Create Date: 2018-08-23 18:00:27
Modify Date: 2026-07-01 13:08:31

Name	2-methylaniline,hydrochloride
Synonyms	Benzenamine,2-methyl-,hydrochloride o-Toluidine Hydrochloride Benzenamine, 2-methyl-, hydrochloride (1:1) 2-toluidinehydrochloride 2-Toluidine hydrochloride 2-METHYLANILINE HYDROCHLORIDE o-Tolylamine hydrochloride MFCD00012959 o-Toluidin hydrochloride 2-methyl-1-aminobenzene hydrochloride Prilocaine Related Compound A (o-toluidine hydrochloride) 2-toluidine,hydrochloride ORTHO-TOLUIDINEHCL ortho-Aminotoluene hydrochloride 2-methylbenzenaminehydrochloride RCRA waste no. U222 o-ToluidineHydrochloride> o-toluidine-HCl o-TOLUIDINE.HCl o-methylanilinehydrochloride nci-c02335 Prilocaine Related Compound A(Hydrochloride) 1-methyl-2-aminobenzene hydrochloride o-Tolidine hydroch toluene,2-amino,hydrochloride 1-amino-2-methylbenzenehydrochloride ortho-methylaniline hydrochloride o-ToluidineHCL Prilocaine Impurity 2(Prilocaine Impurity B HCl) 2-methyl-benzenaminhydrochloride 1-amino-2-methylbenzene hydrochloride 1-methylaniline hydrochloride Prilocaine Hydrochloride Impurity B as Hydrochloride Prilocaine Related Compound A HCl O-TOLUIDINE HYDROCHLORIDE Prilocaine Impurity B HCl 2-Methylaniline hydrochloride (1:1) o-Toluidine Chloride Prilocaine Impurity B o-tolylaminehydrochloride 2-Methylbenzenamine Hydrochloride (o-Toluidine Hydrochloride) 2-Methylaniline hydrochloride O-AMINOTOLUENE HYDROCHLORIDE PRILOCAINE RC A/ORTHO 2-methyl-1-aminobenzenehydrochloride 2-AMINOTOLUENE HYDROCHLORIDE o-methylbenzenaminehydrochloride ortho-aminotoluenehydrochloride 2-Methylanilinhydrochlorid rcrawastenumberu222 PRILOCAINE RELATED COMPOUND A/ORTHO o-Tolidine hydrochloride Prilocaine Impurity 2(Prilocaine Impurity B) Prilocaine Related CoMpound A Prilocaine Impurity 10 HCl o-Toluidinium chloride 2-Toluidine HCl O-TOLUIDINE HYDROCHLORIDE ISO 9001：2015 REACH 2-AMINO-1-METHYLBENZENE HYDROCHLORIDE EINECS 211-252-8 1-methyl-2-aminobenzenehydrochloride Prilocaine Related Compound A as Hydrochloride ORTHO-TOLUIDINEHYDROCHLORIDE o-toluidinhydrochloride O-TOLUIDINIUM CHLORIDE Linagliptin Impurity CD10142 o-Toluidine, hydrochloride 2-methylbenzenaminium chloride O-METHYLANILINE HYDROCHLORIDE o-Aminotoluene Hydrochloride

Boiling Point	242 °C
Melting Point	215-217 °C(lit.)
Molecular Formula	C₇H₁₀ClN
Molecular Weight	143.614
Flash Point	85ºC
Exact Mass	143.050171
PSA	26.02000
LogP	2.96040
Stability	Stable. Incompatible with oxidizing agents, alkalies. Light and moisture sensitive.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XU7350000

CHEMICAL NAME :: o-Toluidine, hydrochloride

CAS REGISTRY NUMBER :: 636-21-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 39

MOLECULAR FORMULA :: C7-H9-N.Cl-H

MOLECULAR WEIGHT :: 143.63

WISWESSER LINE NOTATION :: ZR B1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2951 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27300 mg/kg/13W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 54600 mg/kg/26W-C

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 117 gm/kg/101W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 146 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 159 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Vascular - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 262 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 gm/kg/73W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Blood - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1210 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 233 gm/kg/101W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2142 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12936 gm/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2121 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4242 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12936 gm/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Endocrine - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 750 mg/L

REFERENCE :: TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 2,103,1988 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,155,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8305 No. of Facilities: 32 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 355 (estimated)

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H312 + H332-H350
Precautionary Statements	P201-P280-P308 + P313
Personal Protective Equipment	Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R45
Safety Phrases	S53-S36/37/39-S45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	XU735000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2921430090

88-72-2

636-21-5

Literature: Journal of Organic Chemistry, , vol. 47, # 18 p. 3577 - 3581

HS Code	2921430090
Summary	HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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