22140-20-1

22140-20-1 structure

Name: 2-Methylthio-AMP TEA salt
Chemical Name: 2-methylthioadenosine 5-monophosphate
CAS Number: 22140-20-1
Molecular Formula: C₁₁H₁₆N₅O₇PS
Molecular Weight: 393.31300
Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
Create Date: 2018-06-18 15:03:24
Modify Date: 2024-01-10 19:04:48
2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP is an inhibitor of ADP-dependent platelet aggregation[1][2][3].

Name	2-methylthioadenosine 5-monophosphate
Synonyms	2-methylthioadenosine 5'-monophosphate triethylammonium salt hydrate 2-MeSAMP,2-Methylthio-AMP hydrate triethylammonium salt 2-Methylthio-AMP 2-mesamp 2,6,2',6'-TETRAMETHYLAZOBENZENE NN'-DIOXIDE---CRYSTALLINE 2-methylthioadenosine-5'-monophosphate

Description	2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
Target	P2Y12[1]
In Vitro	2-Methylthio-AMP (2-MeSAMP) inhibits agonist-mediated αIIbβ3 activation in platelets[1]. 2-methylthio-AMP (50 μM; for 5 minutes) does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca2+ mobilization. 2-methylthio-AMP fails to inhibit Ca2+ mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets[1].
References	[1]. John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43. [2]. Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42. [3]. A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22.