2-Methylthio-AMP TEA salt

Modify Date: 2024-01-10 19:04:48

2-Methylthio-AMP TEA salt structure	Common Name	2-Methylthio-AMP TEA salt
	CAS Number	22140-20-1	Molecular Weight	393.31300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₆N₅O₇PS	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of 2-Methylthio-AMP TEA salt

2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP is an inhibitor of ADP-dependent platelet aggregation[1][2][3].

Name	2-methylthioadenosine 5-monophosphate
Synonym	More Synonyms

Description	2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
Target	P2Y12[1]
In Vitro	2-Methylthio-AMP (2-MeSAMP) inhibits agonist-mediated αIIbβ3 activation in platelets[1]. 2-methylthio-AMP (50 μM; for 5 minutes) does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca2+ mobilization. 2-methylthio-AMP fails to inhibit Ca2+ mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets[1].
References	[1]. John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43. [2]. Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42. [3]. A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22.

Molecular Formula	C₁₁H₁₆N₅O₇PS
Molecular Weight	393.31300
Exact Mass	393.05100
PSA	221.18000

2-Methylthio-AMP TEA salt MSDS(Chinese)

2-methylthioadenosine 5'-monophosphate triethylammonium salt hydrate

2-MeSAMP,2-Methylthio-AMP hydrate triethylammonium salt

2-Methylthio-AMP

2-mesamp

2,6,2',6'-TETRAMETHYLAZOBENZENE NN'-DIOXIDE---CRYSTALLINE

2-methylthioadenosine-5'-monophosphate

DC Chemicals Limited
China
Product Name: 2-Methylthio-AMP TEA salt
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-METHYLTHIOADENOSINE 5-MONOPHOSPHATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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2-Methylthio-AMP TEA salt

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