171046-15-4

171046-15-4 structure

Name: FR181157
Chemical Name: sodium,2-[3-[[(1S)-2-(4,5-diphenyl-1,3-oxazol-2-yl)cyclohex-2-en-1-yl]methyl]phenoxy]acetate
CAS Number: 171046-15-4
Molecular Formula: C₃₀H₂₆NNaO₄
Molecular Weight: 487.52
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2017-07-10 03:05:20
Modify Date: 2025-09-18 12:18:13
FR181157, an orally active PGI2 agonist activity with especially good pharmacokinetic properties[1].

Name	sodium,2-[3-[[(1S)-2-(4,5-diphenyl-1,3-oxazol-2-yl)cyclohex-2-en-1-yl]methyl]phenoxy]acetate
Synonyms	Acetic acid,(3-((2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-,sodium salt,(S) Acetic acid,(3-(((1S)-2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-,sodium salt

Description	FR181157, an orally active PGI2 agonist activity with especially good pharmacokinetic properties[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
In Vitro	FR181157 exhibits high binding affinity for the IP receptor with a Ki of 54 nM and anti-aggregative potency with an IC50 of 60 nM[1].
References	[1]. Kouji Hattori , et al. A simple stereoselective synthesis and biological evaluation of FR181157: orally active prostacyclin mimetic. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4277-9.