404009-46-7

404009-46-7 structure

Name: AMA-37
Chemical Name: (2-hydroxy-4-morpholin-4-ylphenyl)-phenylmethanone
CAS Number: 404009-46-7
Molecular Formula: C₁₇H₁₇NO₃
Molecular Weight: 283.32200
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA-PK
Create Date: 2017-09-06 21:03:38
Modify Date: 2024-01-21 08:08:46
AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2].

Name	(2-hydroxy-4-morpholin-4-ylphenyl)-phenylmethanone
Synonyms	AMA37 ArylMorpholine Analog 37 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)-phenyl-methanone DNA-PK Inhibitor V

Description	AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK
Target	IC50: 0.27 μM (DNA-PK)[1].
In Vitro	AMA-37 inhbits PI3K poorly[2]. AMA-37 (20 μM) reduces the ability of UCN-01, isogranulatimide, and debromohymenialdesine, but not caffeine, to overcome G2 arrest (ρ < 0.05)[3]. Inhibition of DNA-PK with AMA37 leads to radiosensitization[3].
References	[1]. Zachary A Knight, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [2]. Zachary A Knight, et al. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem. 2004 Sep 1;12(17):4749-59. [3]. Christopher M Sturgeon, et al. Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Mol Cancer Ther. 2006 Apr;5(4):885-92.