AMA-37

Modify Date: 2024-01-21 08:08:46

AMA-37 structure	Common Name	AMA-37
	CAS Number	404009-46-7	Molecular Weight	283.32200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₇NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AMA-37

AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2].

Name	(2-hydroxy-4-morpholin-4-ylphenyl)-phenylmethanone
Synonym	More Synonyms

Description	AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK
Target	IC50: 0.27 μM (DNA-PK)[1].
In Vitro	AMA-37 inhbits PI3K poorly[2]. AMA-37 (20 μM) reduces the ability of UCN-01, isogranulatimide, and debromohymenialdesine, but not caffeine, to overcome G2 arrest (ρ < 0.05)[3]. Inhibition of DNA-PK with AMA37 leads to radiosensitization[3].
References	[1]. Zachary A Knight, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [2]. Zachary A Knight, et al. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem. 2004 Sep 1;12(17):4749-59. [3]. Christopher M Sturgeon, et al. Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Mol Cancer Ther. 2006 Apr;5(4):885-92.

Molecular Formula	C₁₇H₁₇NO₃
Molecular Weight	283.32200
Exact Mass	283.12100
PSA	49.77000
LogP	2.52480
Storage condition	-20℃

AMA37

ArylMorpholine Analog 37

1-(2-Hydroxy-4-morpholin-4-yl-phenyl)-phenyl-methanone

DNA-PK Inhibitor V

DC Chemicals Limited
China
Product Name: AMA-37
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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