41498-37-7

41498-37-7 structure

Name: GS-389
Chemical Name: 6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline
CAS Number: 41498-37-7
Molecular Formula: C₁₉H₂₃NO₃
Molecular Weight: 313.39100
Catalog: Research Areas Metabolic Disease
Create Date: 2018-08-23 11:44:32
Modify Date: 2025-08-25 15:59:42
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].

Name	6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline
Synonyms	coclaurine dimethyl ether 1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]isoquinoline 7,12-O,O'-dimethylcoclaurine N-(3,4-dimethoxyphenylethyl)-2-(3-methoxyphenyl)acetamide 6,7-dimethoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydroisoquinoline rac-O,O-dimethylcoclaurine GS-389 (+/-)-1-(4-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Description	GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].
Related Catalog	Research Areas >> Metabolic Disease
References	[1]. Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72(4):327-334.

HS Code	2933499090

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%