1575-72-0

1575-72-0 structure
1575-72-0 structure
  • Name: (±)-2-Propyl-4-pentenoic acid
  • Chemical Name: (+/-)-2-Propyl-4-pentenoic Acid
  • CAS Number: 1575-72-0
  • Molecular Formula: C8H14O2
  • Molecular Weight: 142.19600
  • Catalog: Research Areas Others
  • Create Date: 2018-08-27 11:13:52
  • Modify Date: 2024-01-09 20:39:48
  • (±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity[1][2].

Name (+/-)-2-Propyl-4-pentenoic Acid
Synonyms 2-propyl-4-pentenoic acid
Description (±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity[1][2].
Related Catalog
In Vitro (±)-2-Propyl-4-pentenoic acid (1 mM; 26 h) induces approximately 50% of dysmorphogenic mouse embryos[2].
References

[1]. W Tang, et, al. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics. Drug Metab Dispos. 1997 Feb;25(2):219-27.

[2]. Gofflot F, et, al. In vitro neuroteratogenicity of valproic acid and 4-en-VPA. Neurotoxicol Teratol. Jul-Aug 1995;17(4):425-35.

Density 0.943g/cm3
Boiling Point 228.8ºC at 760mmHg
Molecular Formula C8H14O2
Molecular Weight 142.19600
Flash Point 126.2ºC
Exact Mass 142.09900
PSA 37.30000
LogP 2.06340
Vapour Pressure 0.0257mmHg at 25°C
Index of Refraction 1.448
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SB3362000
CHEMICAL NAME :
4-Pentenoic acid, 2-propyl-
CAS REGISTRY NUMBER :
1575-72-0
BEILSTEIN REFERENCE NO. :
1704069
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H14-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1160 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 24,427,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 24,427,1985
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Hazard Codes T
RIDADR UN 2810 6.1 / PGIII
RTECS SB3362000
HS Code 2916190090
HS Code 2916190090
Summary 2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%