70310-73-5
70310-73-5 structure
- Name: ()-Eseroline fumarate salt
- Chemical Name: (3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-ol,(E)-but-2-enedioic acid
- CAS Number: 70310-73-5
- Molecular Formula: C17H22N2O5
- Molecular Weight: 334.36700
- Catalog: analytical chemistry Standard Forensic and veterinary standards
- Create Date: 2017-12-09 07:58:59
- Modify Date: 2025-08-25 11:44:38
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(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum[1][2].
| Name | (3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-ol,(E)-but-2-enedioic acid |
|---|---|
| Synonyms |
(-)-Eseroline fumarate salt
(u2212)-Eseroline fumarate salt E100_FLUKA |
| Description | (-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | (-)-Eseroline fumarate (0.5 mM; 0-25 hr) 时间依赖性地诱导小鼠神经母细胞瘤 N1E-115、大鼠胶质瘤 C6 和神经母细胞癌-胶质瘤杂交 NG 108-15 中的 LDH 泄露[1]。 |
| In Vivo | (-)-Eseroline fumarate (盐酸; 10 mg/kg; 静脉注射; 单剂量) 诱导成年杂种猫的大脑皮层释放5-HT[2]。 (-)-Eseroline fumarate (水杨酸; 9 mg/kg; 皮下注射; 单剂量) 在小鼠甩尾试验中显示出镇痛的作用，并强烈地降低 Physostigmine (HY-N6608) 的抗伤害作用[3]。 |
| References |
| Molecular Formula | C17H22N2O5 |
|---|---|
| Molecular Weight | 334.36700 |
| Exact Mass | 334.15300 |
| PSA | 101.31000 |
| LogP | 1.47600 |
| Appearance | white |
| Storage condition | 2-8°C |
| Water Solubility | 0.1 M HCl: soluble (Solutions should be freshly prepared.) |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |