()-Eseroline fumarate salt
()-Eseroline fumarate salt structure
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Common Name | ()-Eseroline fumarate salt | ||
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| CAS Number | 70310-73-5 | Molecular Weight | 334.36700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H22N2O5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of ()-Eseroline fumarate salt(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum[1][2]. |
| Name | (3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-ol,(E)-but-2-enedioic acid |
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| Synonym | More Synonyms |
| Description | (-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum[1][2]. |
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| Related Catalog | |
| In Vitro | (-)-Eseroline fumarate (0.5 mM; 0-25 hr) 时间依赖性地诱导小鼠神经母细胞瘤 N1E-115、大鼠胶质瘤 C6 和神经母细胞癌-胶质瘤杂交 NG 108-15 中的 LDH 泄露[1]。 |
| In Vivo | (-)-Eseroline fumarate (盐酸; 10 mg/kg; 静脉注射; 单剂量) 诱导成年杂种猫的大脑皮层释放5-HT[2]。 (-)-Eseroline fumarate (水杨酸; 9 mg/kg; 皮下注射; 单剂量) 在小鼠甩尾试验中显示出镇痛的作用，并强烈地降低 Physostigmine (HY-N6608) 的抗伤害作用[3]。 |
| References |
| Molecular Formula | C17H22N2O5 |
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| Molecular Weight | 334.36700 |
| Exact Mass | 334.15300 |
| PSA | 101.31000 |
| LogP | 1.47600 |
| Appearance of Characters | white |
| Storage condition | 2-8°C |
| Water Solubility | 0.1 M HCl: soluble (Solutions should be freshly prepared.) |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Reversible inhibition of acetylcholinesterase by eseroline, an opioid agonist structurally related to physostigmine (eserine) and morphine.
Biochem. Pharmacol. 31 , 1233, (1982) The action of eseroline--(3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indo l-5-ol--salicylate was tested on preparations of ChE from different sources and on the longitudinal muscle... |
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Direct evidence that eseroline possesses morphine-like effects.
Eur. J. Pharmacol. 83 , 232, (1982) The opiate-like effects of eseroline, a physostigmine derivative, were studied in different tests. The antinociceptive effect of eseroline given s.c. and intracerebrally could be detected in the rat h... |
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Eseroline, a metabolite of physostigmine, induces neuronal cell death.
Toxicol. Appl. Pharmacol. 106 , 28, (1990) The toxic effects of physostigmine, an anticholinesterase drug, and its metabolite eseroline were investigated in three neuronal cell culture systems, mouse neuroblastoma N1E-115, rat glioma C6, and n... |
| (-)-Eseroline fumarate salt |
| (u2212)-Eseroline fumarate salt |
| E100_FLUKA |