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660843-21-0

660843-21-0 structure
660843-21-0 structure
  • Name: Mal-PEG2-NH-Boc
  • Chemical Name: tert-butyl N-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethyl]carbamate
  • CAS Number: 660843-21-0
  • Molecular Formula: C15H24N2O6
  • Molecular Weight: 328.36100
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-12-08 05:25:55
  • Modify Date: 2024-01-10 20:13:01
  • Mal-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name tert-butyl N-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethyl]carbamate
Description Mal-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C15H24N2O6
Molecular Weight 328.36100
Exact Mass 328.16300
PSA 97.66000
LogP 0.61160
Precursor  0

DownStream  1