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660843-21-0

660843-21-0 structure

660843-21-0 structure

Name: Mal-PEG2-NH-Boc
Chemical Name: tert-butyl N-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethyl]carbamate
CAS Number: 660843-21-0
Molecular Formula: C₁₅H₂₄N₂O₆
Molecular Weight: 328.36100
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-12-08 05:25:55
Modify Date: 2026-07-16 11:09:43
Mal-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	tert-butyl N-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethyl]carbamate
Synonyms	Cbamic acid, N-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester tert-Butyl {2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethyl}cbamate O-[2-(Boc-amino)ethyl]-O′-(2-maleimidoethyl)ethylene glycol O-[2-(Boc-amino)ethyl]-O'-(2-maleimidoethyl)ethylene glycol >= (HPLC)

Description	Mal-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₅H₂₄N₂O₆
Molecular Weight	328.36100
Exact Mass	328.16300
PSA	97.66000
LogP	0.61160

Precursor 0
DownStream 1
660843-23-2

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