Mal-PEG2-NH-Boc

Modify Date: 2024-01-10 20:13:01

Mal-PEG2-NH-Boc Structure
Mal-PEG2-NH-Boc structure
Common Name Mal-PEG2-NH-Boc
CAS Number 660843-21-0 Molecular Weight 328.36100
Density N/A Boiling Point N/A
Molecular Formula C15H24N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mal-PEG2-NH-Boc


Mal-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name tert-butyl N-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethyl]carbamate

 Mal-PEG2-NH-Boc Biological Activity

Description Mal-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C15H24N2O6
Molecular Weight 328.36100
Exact Mass 328.16300
PSA 97.66000
LogP 0.61160

 Precursor & DownStream

Precursor  0

DownStream  1