Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TAK-438
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

1260141-27-2

1260141-27-2 structure

1260141-27-2 structure

Name: Vonoprazan Fumarate (TAK-438)
Chemical Name: Vonoprazan Fumarate
CAS Number: 1260141-27-2
Molecular Formula: C₂₁H₂₀FN₃O₆S
Molecular Weight: 461.463
Catalog: Pharmaceutical intermediate API intermediate
Create Date: 2018-07-14 18:58:25
Modify Date: 2026-06-30 16:31:53
TAK-438 is an orally active potassium-competitive acid blocker which inhibits H+, K+-ATPase activity with an IC50 of 19 nM.

Name	Vonoprazan Fumarate
Synonyms	Vonoprazan-025-Salt2 Vorolazan fumate 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-, 2-butenedioate (1:1) Vonoprazan fumate(TAK-438) 1-[5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine (2E)-2-butenedioate (1:1) fuMate vonoprazan 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine Vonoprazan Fumate-D3Q: What is Vonoprazan Fumate-D3 Q: What is the CAS Number of Vonoprazan Fumate-D3 vonaprazan(TK-438) vonoprazan(tak-438)1260-2 Vonaprazan Vonoprazan FuMate 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate TAK 438,Vonoprazan 4-Aminopyrazolo[3 TAK-438 //BP Voranolazan fumate Fumate Vorosuvate 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate TAK VONOPRAZAN FUMATE NON-STERILE BULK DRUG SUBSTANCE Wonazan Fumate 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate (Vonoprazan fumate) Vonoprazon Fumate TAK-438 Vonoprazan fumate Vonaprazan(TAK-438) 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate (Vonoprazan) 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine (2E)-2-butenedioate VONOPRAZAN FUMATE (TAK-438);TAK-438 AK-438 TAK-438 ISO 9001：2015 REACH 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmeth anamine fumate Vonorasen fumate Vonorazon 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-, (2E)-2-butenedioate (1:1) TAK-438 Fluorine Prazan 1-(5-(2-FLUOROPHENYL)-1-(PYRIDIN-4-YLSULFONYL)-1H-PYRROL-3-YL)-N-METHYLMETHANAMINE Vonoprazan fumate API TAK-438 Vonoprazan fumate, 10 mM in DMSO vonoprazan(tak-438) Vonoprazan Fumate DISCONTINUED PLEASE SEE V767013 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine,(E)-4-oxopent-2-enoic acid Vonoprazan Vonoprazan onoprazan Vonoprazan fumate Fumate vonolasan vomoprazan fumate TAK 438; TAK438 Vonolazan Fumate API

Description	TAK-438 is an orally active potassium-competitive acid blocker which inhibits H+, K+-ATPase activity with an IC50 of 19 nM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Endocrinology
References	[1]. Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456. [2]. Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238. [3]. Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.

Molecular Formula	C₂₁H₂₀FN₃O₆S
Molecular Weight	461.463
Exact Mass	461.105682
PSA	146.97000
LogP	3.82910

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.