1260141-27-2

• 常用中文名：富马酸沃诺拉赞
• 常用英文名：Vonoprazan Fumarate (TAK-438)
• CAS号：1260141-27-2
• 分子式：C₂₁H₂₀FN₃O₆S
• 分子量：461.463
• 相关类别： 医药中间体 原料药中间体
• 发布时间：2018-07-14 18:58:25
• 更新时间：2026-06-30 16:31:53
• TAK-438是有一种口服活性的钾竞争性酸阻断剂,抑制H+, K+-ATPase的 IC50 值为19 nM。
• 富马酸沃诺拉赞(TAK-438)属于钾离子（K+）竞争性酸阻滞剂（P-CAB）, 是一种可逆性质子泵抑制剂，本品进入人体后，在胃壁细胞泌酸的最后步骤，通过抑制K+与H+-K+-ATP酶（质子泵）的结合，终止胃酸的分泌，达到抑酸效果，本品具有强劲、持久的抑制胃酸分泌作用。

名称

• 中文名: 富马酸沃诺拉赞
• 英文名: Vonoprazan Fumarate
• 中文别名: 沃诺拉赞富马酸盐; 富马酸沃诺拉赞 富马酸伏诺拉生; 富马酸伏洛拉升; 富马酸伏沃拉生; 5-(2-氟苯基)-N-甲基-1-(3-吡啶基磺酰基)-1H-吡咯-3-甲胺富马酸盐 (富马酸沃诺拉赞); 富马酸凡诺帕胺; 伏诺拉生; 富马酸沃诺普啶; 富马沃诺拉赞; 氟呐普拉赞; 1-(5-(2-氟苯基)-1-(吡啶-3-基磺酰基)-1H-吡咯-3-基)-N-甲基甲胺2-丁烯二酸盐; 富马酸诺诺宗; 富马酸沃诺拉赞-D3; 富马酸伏诺拉生; 富马酸沃诺拉赞(TAK-438); 富马酸沃诺拉赞,10 MM DMSO 溶液; 富马酸沃诺哌嗪-D4; 5-(2-氟苯基)-N-甲基-1-(3-吡啶基磺酰基)-1H-吡咯-3-甲胺富马酸盐 (氟呐普拉赞); 富马酸沃诺拉赞高含量原粉品质保障; Vonoprazan Fumate (TAK-438) 富马酸沃诺拉赞,S8016; 富马酸沃诺拉赞,氟呐普拉赞; 氟呐普拉赞原料药; 富马酸沃诺拉赞和富马酸福诺拉生; 富马酸沃诺拉赞(伏诺拉生); 富马酸伏洛拉生对照品; TAK-438工艺,中间体及其杂质; 富马酸沃诺拉赞,Vonoprazan fumate; 5-(2-氟苯基)-N-甲基-1-(3-吡啶基磺酰基)-1H-吡咯-3-甲胺富马酸盐(1:1); 富马酸沃诺拉赞(TAK-438, VONOPRAZAN FUMATE); 富马酸氟诺普拉赞; 文诺普兰标准品LT2; 富马酸沃诺拉生; TAK-438 沃诺拉赞; 富马酸沃诺拉赞API; 富马酸沃诺拉赞及中间体; Vonoprazan Fumate (TAK-438) 富马酸沃诺拉赞，S8016; 5-(2-氟苯基)-N-甲基-1-(3-吡啶基磺酰基)-1H-吡咯-3-甲胺富马酸盐; 富马酸文诺普兰; 5-(2-氟苯基)-N-甲基-1-(3-吡啶基磺酰基)-1H-吡咯-3-甲胺富马酸盐 TAK-438; 富马酸伏诺拉生 Vonoprazan fumate; 沃诺拉赞标准品LT2; 恩科富马酸沃诺拉赞; 沃拉帕赞富马酸盐; 价伏诺拉生 富马酸盐形式; 伏诺拉生标准品LT2; 富马酸沃诺他赞(TAK-438,)杂质; 富马酸沃诺拉赞/富马酸凡诺帕胺; 富马酸沃诺拉赞(TAK438,API)
• 英文别名: Vonoprazan-025-Salt2; Vorolazan fumate; 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate; 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-, 2-butenedioate (1:1); Vonoprazan fumate(TAK-438); 1-[5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine (2E)-2-butenedioate (1:1); fuMate vonoprazan; 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine; Vonoprazan Fumate-D3Q: What is Vonoprazan Fumate-D3 Q: What is the CAS Number of Vonoprazan Fumate-D3; vonaprazan(TK-438); vonoprazan(tak-438)1260-2; Vonaprazan; Vonoprazan FuMate; 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate; TAK 438,Vonoprazan; 4-Aminopyrazolo[3; TAK-438 //BP; Voranolazan fumate; Fumate Vorosuvate; 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate TAK; VONOPRAZAN FUMATE NON-STERILE BULK DRUG SUBSTANCE; Wonazan Fumate; 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate (Vonoprazan fumate); Vonoprazon Fumate; TAK-438 Vonoprazan fumate; Vonaprazan(TAK-438); 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate (Vonoprazan); 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine (2E)-2-butenedioate; VONOPRAZAN FUMATE (TAK-438);TAK-438; AK-438; TAK-438 ISO 9001：2015 REACH; 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmeth anamine fumate; Vonorasen fumate; Vonorazon; 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-, (2E)-2-butenedioate (1:1); TAK-438 Fluorine Prazan; 1-(5-(2-FLUOROPHENYL)-1-(PYRIDIN-4-YLSULFONYL)-1H-PYRROL-3-YL)-N-METHYLMETHANAMINE; Vonoprazan fumate API; TAK-438; Vonoprazan fumate, 10 mM in DMSO; vonoprazan(tak-438); Vonoprazan Fumate DISCONTINUED PLEASE SEE V767013; 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine,(E)-4-oxopent-2-enoic acid; Vonoprazan Vonoprazan onoprazan Vonoprazan fumate; Fumate vonolasan; vomoprazan fumate; TAK 438; TAK438; Vonolazan Fumate API

物化性质

• 分子式: C₂₁H₂₀FN₃O₆S
• 分子量: 461.463
• 精确质量: 461.105682
• PSA: 146.97000
• LogP: 3.82910

生物活性

• 描述: TAK-438是有一种口服活性的钾竞争性酸阻断剂,抑制H+, K+-ATPase的 IC50 值为19 nM。
• 相关类别:
  信号通路 >> 跨膜转运 >> 质子泵
  研究领域 >> 内分泌
• 参考文献:

  [1]. Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456.

  [2]. Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238.

  [3]. Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.