Name | 7-(β-Hydroxypropyl)theophylline |
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Synonyms |
MFCD00022833
7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione (1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine) EINECS 210-028-7 Proxyphylline 7-(2-Hydroxypropyl)theophylline |
Description | Proxyphylline is a methylxanthine derivative clinical used as cardiac stimulant, vasodilator and bronchodilator. |
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Related Catalog | |
In Vitro | Proxyphylline has shown vasodilatory and cardiac stimulatory effects. Proxyphylline produces an increase in the coronary flow associated with a definite positive inotropic effect[1]. Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline[2] |
In Vivo | In a double-blind cross-over study, proxyphylline exhibits bronchodilatory effect[3]. Proxyphylline inhibits cAMP and cGMP hydrolysis in human lung tissue. The apparent inhibition constant of proxyphylline is 0.06-0.7 mM at low cAMP concentrations and it is 1.0 mM at high cAMP concentrations[3]. |
References |
Density | 1.46 g/cm3 |
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Boiling Point | 487.2ºC |
Melting Point | 134-136ºC |
Molecular Formula | C10H14N4O3 |
Molecular Weight | 238.24300 |
Flash Point | 248.5ºC |
Exact Mass | 238.10700 |
PSA | 82.05000 |
Index of Refraction | 1.664 |
Storage condition | Refrigerator |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
![]() GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Precautionary Statements | P301 + P312 + P330 |
Hazard Codes | Xn |
Risk Phrases | 22 |
Safety Phrases | 36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | XH5907500 |
HS Code | 2939590000 |
~% 603-00-9 |
Literature: Bulletin de la Societe Chimique de France, , p. 1773,1775 |
~% 603-00-9 |
Literature: Journal of Medicinal Chemistry, , vol. 42, # 14 p. 2527 - 2534 |
~% 603-00-9 |
Literature: US2715125 , ; |
~% 603-00-9 |
Literature: US2715125 , ; |
~% 603-00-9 |
Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 292, p. 234,236,237 |
~% 603-00-9 |
Literature: Bulletin de la Societe Chimique de France, , p. 1773,1775 |
Precursor 5 | |
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DownStream 0 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |