Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Diuron
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China
Product Name: Diuron
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DC Chemicals Limited
China
Product Name: Diuron
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Henan Tianfu Chemical Co., Ltd.
China
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330-54-1

330-54-1 structure

Name: Diuron
Chemical Name: diuron
CAS Number: 330-54-1
Molecular Formula: C₉H₁₀Cl₂N₂O
Molecular Weight: 233.094
Catalog: Chemical pesticide herbicide Other herbicides
Create Date: 2018-02-12 08:00:00
Modify Date: 2024-01-02 18:36:31
Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male and female mice by 73 and 27%, respectively.

Name	diuron
Synonyms	3-(3,4-Dichloro-phenyl)-1,1-dimethyl-urea MFCD00018136 1-(3,4-dichlorophenyl)-3,3-dimethylurea Diuron 1,1-Dimethyl-3-(3,4-Dichlorophenyl)urea N-(3,4-Dichlorophenyl)-N,N-Dimethylurea 3-(3,4-dichlorophenyl)-1,1-dimethyl-urea Urea, 3-(3,4-dichlorophenyl)-1,1-dimethyl- Urea, N'-(3,4-dichlorophenyl)-N,N-dimethyl- dichlorfenidim 3-(3,4-Dichlorophenyl)-1,1-dimethylurea DCMU N’-(3,4-dichlorophenyl)-N,N-dimethylurea EINECS 206-354-4

Description	Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male and female mice by 73 and 27%, respectively.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others

Density	1.3±0.1 g/cm3
Boiling Point	362.3±52.0 °C at 760 mmHg
Melting Point	158-159°C
Molecular Formula	C₉H₁₀Cl₂N₂O
Molecular Weight	233.094
Flash Point	172.9±30.7 °C
Exact Mass	232.017014
PSA	32.34000
LogP	2.88
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.565
Stability	Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS8925000

CHEMICAL NAME :: Urea, 3-(3,4-dichlorophenyl)-1,1-dimethyl-

CAS REGISTRY NUMBER :: 330-54-1

BEILSTEIN REFERENCE NO. :: 2215168

LAST UPDATED :: 199712

DATA ITEMS CITED :: 36

MOLECULAR FORMULA :: C9-H10-Cl2-N2-O

MOLECULAR WEIGHT :: 233.11

WISWESSER LINE NOTATION :: GR BG DMVN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1017 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52500 ug/kg/30D-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13620 mg/kg/61W-C

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/m3/4H/60D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Blood - changes in spleen Endocrine - changes in thyroid weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 153 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 360 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1250 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1935 mg/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,353,1978 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993 OEL-BELGIUM:TWA 10 mg/m3 JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FINLAND:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993 OEL-FRANCE:TWA 10 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 10 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIURON-air:10H TWA 10 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0785 No. of Facilities: 120 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 374 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0785 No. of Facilities: 75 (estimated) No. of Industries: 8 No. of Occupations: 12 No. of Employees: 4216 (estimated) No. of Female Employees: 264 (estimated)

Symbol	GHS07, GHS08, GHS09
Signal Word	Warning
Hazard Statements	H302-H351-H373-H410
Precautionary Statements	P260-P280-P301 + P312 + P330
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	O,C
Risk Phrases	R22;R40;R48/22;R50/53
Safety Phrases	13-22-23-37-46-60-61-2-36/37-26
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	YS8925000
Packaging Group	III
Hazard Class	9
HS Code	2924299032

95-76-1

79-44-7

~94%

330-54-1

Literature: Degani, Iacopo; Fochi, Rita; Magistris, Claudio; Migliaccio, Mara Synthesis, 2009 , # 5 p. 801 - 808

7159-94-6

124-40-3

~92%

330-54-1

Literature: Manov-Yuvenskii, V. I.; Kuznetsov, S. L. Russian Journal of Applied Chemistry, 1993 , vol. 66, # 6.2 p. 1063 - 1069 Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1993 , vol. 66, # 6 p. 1319 - 1327

2327-02-8

124-40-3

~87%

330-54-1

2150-28-9

124-40-3

~80%

330-54-1

124-40-3

102-36-3

330-54-1

Literature: Bl.Res.Coun.Israel , , vol. 7, p. 135 US2855445 , ;

10248-88-1

~73%

330-54-1

Literature: Ramadas; Janarthanan Synthetic Communications, 1997 , vol. 27, # 13 p. 2357 - 2362

124-40-3

95-76-1

330-54-1

Literature: US2857430 , ;

201230-82-2

124-40-3

95-76-1

330-54-1

Literature: Journal of Organic Chemistry, , vol. 27, p. 4341 - 4346

Precursor 9
95-76-1 79-44-7 7159-94-6 124-40-3
2327-02-8 2150-28-9 102-36-3 10248-88-1
201230-82-2
DownStream 10
74-89-5 34637-13-3 3567-62-2 69342-26-3
76409-92-2 51207-31-9 1746-01-6 124-38-9
95-76-1 124-40-3

HS Code	2924299032
Summary	2924299032 1,1-dimethyl-3-(3-(trifluoromethyl)phenyl)urea。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

330-54-1	1007536-67-5
15500-95-5	10290-37-6
3567-62-2	2327-02-8
8065-33-6	59989-02-5
8071-35-0	1158522-08-7
940364-43-2	2137063-23-9
134104-43-1	2227913-00-8
131615-57-1	6906-52-1
930439-75-1	2228474-98-2
1018584-77-4