Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(4-(N-(5-METHYLISOXAZOL-3-YL)SULFAMOYL)PHENYL)ACETAMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

21312-10-7

21312-10-7 structure

Name: N4-Acetylsulfamethoxazole
Chemical Name: N-acetylsulfamethoxazole
CAS Number: 21312-10-7
Molecular Formula: C₁₂H₁₃N₃O₄S
Molecular Weight: 295.31400
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-03-04 08:00:00
Modify Date: 2025-08-25 18:07:35
N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections[1].

Name	N-acetylsulfamethoxazole
Synonyms	Sulfamethoxazole impurity A N-Acetyl Sulfamethoxazole N4-Acetylsulfamethoxazole N-[4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]acetamide N-{4-{[(5-Methyl-3-isoxazolyl)amino]sulfonyl}phenyl}acetamide Sulfisomezole-N4-acetate Sulfamethoxazole EP Impurity A

Description	N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections[1].
Related Catalog	Research Areas >> Infection Research Areas >> Metabolic Disease Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. https://pubchem.ncbi.nlm.nih.gov/compound/Acetylsulfamethoxazole

Density	1.448g/cm3
Melting Point	222ºC dec.
Molecular Formula	C₁₂H₁₃N₃O₄S
Molecular Weight	295.31400
Exact Mass	295.06300
PSA	109.68000
LogP	2.96900
Index of Refraction	1.622
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE4935000

CHEMICAL NAME :: Acetanilide, 4'-((5-methyl-3-isoxazolyl)sulfamoyl)-

CAS REGISTRY NUMBER :: 21312-10-7

BEILSTEIN REFERENCE NO. :: 0285801

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H13-N3-O4-S

MOLECULAR WEIGHT :: 295.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3471 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,27,1990

RIDADR	NONH for all modes of transport
HS Code	2935009090

1072-67-9

121-60-8

~80%

21312-10-7

Literature: Brimacombe, Kyle R.; Walsh, Martin J.; Liu, Li; Vasquez-Valdivieso, Montserrat G.; Morgan, Hugh P.; McNae, Iain; Fothergill-Gilmore, Linda A.; Michels, Paul A. M.; Auld, Douglas S.; Simeonov, Anton; Walkinshaw, Malcolm D.; Shen, Min; Boxer, Matthew B. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 12 - 17

723-46-6

75-36-5

~71%

21312-10-7

Literature: Wang, Gong-Bao; Wang, Lin-Fa; Li, Chao-Zhang; Sun, Jing; Zhou, Guang-Ming; Yang, Da-Cheng Research on Chemical Intermediates, 2012 , vol. 38, # 1 p. 77 - 89

29699-89-6

21312-10-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 10, p. 572 - 575

723-46-6

108-24-7

21312-10-7

Literature: Chemosphere, , vol. 57, # 11 p. 1733 - 1738

723-46-6

21312-10-7

Literature: Journal of Pharmacology and Experimental Therapeutics, , vol. 274, # 3 p. 1099 - 1104

98-74-8

21312-10-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 10, p. 572 - 575

97254-40-5

21312-10-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 10, p. 572 - 575

99447-77-5

21312-10-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 10, p. 572 - 575

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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