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145672-81-7

145672-81-7 structure
145672-81-7 structure
  • Name: Cetrorelix Acetate
  • Chemical Name: cetrorelix acetate
  • CAS Number: 145672-81-7
  • Molecular Formula: C72H96ClN17O16
  • Molecular Weight: 1491.09000
  • Catalog: Peptides
  • Create Date: 2017-08-09 02:52:39
  • Modify Date: 2024-01-03 12:50:04
  • Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. Sequence: N-acetyl-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-Ser-Tyr-{Cit}-Leu-Arg-Pro-Ala-NH2.

Name cetrorelix acetate
Description Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. Sequence: N-acetyl-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-Ser-Tyr-{Cit}-Leu-Arg-Pro-Ala-NH2.
Related Catalog
Target

IC50: 1.21 nM GnRH[1].

In Vitro Cetrorelix Acetate inhibits growth of ES-2 cell line at 1000 ng/ml. Cetrorelix Acetate has comparable antiproliferative effects as GnRH-I agonists indicating that the dichotomy of GnRH-I agonists and antagonists might not apply to the GnRH-I system in cancer cells[2].
References

[1]. Beckers T et al. Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal Biochem. 1997 Aug 15;251(1):17-23.

[2]. Gründker C et al. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003 Oct 7;1:65.

Molecular Formula C72H96ClN17O16
Molecular Weight 1491.09000
Exact Mass 1489.69000
PSA 532.97000
LogP 6.02320
Storage condition -20°C
Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H361
Precautionary Statements P281
RIDADR NONH for all modes of transport