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434-03-7

434-03-7 structure
434-03-7 structure
Name ethisterone
Synonyms NSC-9565
Progestoral
Produxan
17α-Ethynyl-17β-hydroxyandrost-4-en-3-one
pregneninolo
17alpha-Ethynyl-17beta-hydroxyandrost-4-en-3-one
lucorteumoral
17α-Ethinyltestosterone
(8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
(17-alpha)-pregn-4-en-20-yn-3-on
Lutidon Oral
ETHYNYLANDROSTENOLONE
Anhydrohydroxyprogesterone
Lucorteum Oral
Lutocylol
17-α-Ethynyltestosterone
17ALPHA-ETHYNYLTESTOSTERONE
17-β-Hydroxy-17-α-ethynyl-4-androsten-3-one
Ethisterone 0
4,17A-PREGNEN-17B-OL-20-YNE
17a-Ethynyl-17b-hydroxy-4-androsten-3-one
lutidonoral
4,17a-pregnen-17b-ol-20-yn-3-one
Prone
Trosinone
ANHYDROXYPROGESTERONE
Progestolets
Pregn-4-en-20-yn-3-one, 17-hydroxy-, (17alpha)
Nugestoral
Lutocyclin
4-ANDROSTEN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE
EINECS 207-093-9
Ethisterone a progestogen hormone being considered to treat prostate cancer
17β-Hydroxy-4,17α-pregnen-20-yn-3-one
Prodroxan
Nalutoral
Gestoral
17a-Ethynyl-4-androsten-17b-ol-3-one
Pranone
Ethinyltestosterone
primolutc
Pregneninolone
4,17α-Pregnen-17β-ol-20-yn-3-one
(17α)-17-hydroxy-pregn-4-en-20-yn-3-one
4,17ALPHA-PREGNEN-17BETA-OL-20-YN-3-ONE
progestinp
ETHYNYLTESTOSTERONE
17a-ethynyl-17b-hydroxy-4-androsten-3-one
MFCD00002476
Ethinone
17-alpha-ethinyltestosterone
Primolut C
17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one
17A-ETHYNYLTESTOSTERONE
Prolutol
Proluton C
Prodoxan
17α-Ethynyltestosterone
Ora-Lutin
17a-Ethynyltestosterone
ANHYDROHYDROXYPROGESTERONE
Lutocyclol
17-Ethynyl-17β-hydroxyandrost-4-en-3-one
(17α)-17-Hydroxypregn-4-en-20-yn-3-one
17a-Ethinyltestosterone
17b-hydroxy-4,17a-pregnen-20-yn-3-one
Aethisteron
17BETA-HYDROXY-4,17ALPHA-PREGNEN-20-YN-3-ONE
Colutoid
Ethisterone,17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one
ETHISTERONE(RG)(CALL)
ETHINYL TESTOSTERONE
ETHISTERONE
Progestab
17A-ETHYNYL-4-ANDROSTEN-17B-OL-3-ONE
(8R,9S,10R,13S,14S,17S)-17-ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
(8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHY
Pregnin
ETHISTERONE(RG)
Progestin P
Syngestrotabs
Anhydroxyprogesterone
Density 1.1±0.1 g/cm3
Boiling Point 446.4±45.0 °C at 760 mmHg
Melting Point 266-273ºC
Molecular Formula C21H28O2
Molecular Weight 312.446
Flash Point 190.2±21.3 °C
Exact Mass 312.208923
PSA 37.30000
LogP 3.86
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.572
Storage condition 2~8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5570250
CHEMICAL NAME :
17-alpha-Pregn-4-en-20-yn-3-one, 17-hydroxy-
CAS REGISTRY NUMBER :
434-03-7
BEILSTEIN REFERENCE NO. :
1889895
LAST UPDATED :
199612
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C21-H28-O2
MOLECULAR WEIGHT :
312.49
WISWESSER LINE NOTATION :
L E5 B666 OV MUTJ A1 E1 FQ F1UU1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
168 mg/kg
SEX/DURATION :
female 3 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 76,626,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
386 mg/kg
SEX/DURATION :
female 6-28 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 84,962,1962
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
21 mg/kg
SEX/DURATION :
female 11-15 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952- Volume(issue)/page/year: 19,1369,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
81900 ug/kg
SEX/DURATION :
female 16-28 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952- Volume(issue)/page/year: 19,1369,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
79800 ug/kg
SEX/DURATION :
female 8-26 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952- Volume(issue)/page/year: 18,559,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
56 mg/kg
SEX/DURATION :
female 15-39 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952- Volume(issue)/page/year: 18,559,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
56 mg/kg
SEX/DURATION :
female 15-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952- Volume(issue)/page/year: 18,559,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
92 mg/kg
SEX/DURATION :
female 7-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 11,148,1960
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
200 mg/kg
SEX/DURATION :
female 17-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 24,77,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 5,282,1954
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
288 mg/kg
SEX/DURATION :
male 9 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,540,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
10 mg/kg
SEX/DURATION :
male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,540,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
280 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,57,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
140 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,57,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
5 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 28,18,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80411 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80411 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H360
Precautionary Statements P201-P308 + P313
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn:Harmful
Risk Phrases R40;R48
Safety Phrases S22-S24/25
RIDADR UN 2811
WGK Germany 3
RTECS TU5570250
Hazard Class 6.1
HS Code 2942000000
20380-17-0 structure

20380-17-0

~%

434-03-7 structure

434-03-7

640-87-9 structure

640-87-9

Literature: The Upjohn Company Patent: US4041055 A1, 1977 ;
63-05-8 structure

63-05-8

74-86-2 structure

74-86-2

~95%

434-03-7 structure

434-03-7

Literature: Kataoka, Hideaki; Watanabe, Kiyoshi; Miyazaki, Ken-ichi; Tahara, Shin-ichiro; Ogu, Ken-ichi; et al. Chemistry Letters, 1990 , # 9 p. 1705 - 1708
3604-60-2 structure

3604-60-2

~%

434-03-7 structure

434-03-7

Literature: Inhoffen et al. Chemische Berichte, 1938 , vol. 71, p. 1024,1030 Full Text Show Details Schering Corp. Patent: US2323911 , 1937 ;
24594-68-1 structure

24594-68-1

~%

434-03-7 structure

434-03-7

Literature: Inhoffen; Koester Chemische Berichte, 1939 , vol. 72, p. 595,596
63-05-8 structure

63-05-8

~%

434-03-7 structure

434-03-7

Literature: Schering A.G. Patent: DE1016707 , 1957 ;
HS Code 2942000000
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