85541-78-2
85541-78-2 structure
- Name: [Glu2]-TRH
- Chemical Name: [Glu2]-TRH
- CAS Number: 85541-78-2
- Molecular Formula: C15H22N4O6
- Molecular Weight: 354.35800
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-12-05 12:39:59
- Modify Date: 2024-01-13 12:06:50
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(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1].
| Name | [Glu2]-TRH |
|---|---|
| Synonyms |
GLP-GLU-PRO-NH2
PE-E-P-NH2 fertilization promoting peptide FPP (GLU2)-TRH PYR-GLU-PRO-NH2 PGLU-GLU-PRO AMIDE PYROGLU-GLU-PRO AMIDE FPP,Fertilization-ProMoting Peptide pyroglutamyl-glutamyl-prolineamide |
| Description | (Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1]. |
|---|---|
| Related Catalog | |
| In Vivo | (Glu2)-TRH (1-100 μmol/kg; 静脉注射) 剂量依赖性地减弱 TRH 诱导的兴奋作用[1]。 (Glu2)-TRH (10 μmol/kg; 静脉注射) 在戊巴比妥 (60 mg/kg; 腹腔) 前 10 分钟给药，与载体治疗组相比，睡眠时间减少了大约 20%[1]。 Animal Model: Male Swiss-Webster mice (30 g)[1] Dosage: 1, 2, 5, 10, 15, 25, 50, 100 μmol/kg Administration: IV; 10 min before Pentobarbital (60 mg/kg, i.p.) Result: Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action. |
| References |
| Density | 1.416g/cm3 |
|---|---|
| Boiling Point | 899.9ºC at 760 mmHg |
| Molecular Formula | C15H22N4O6 |
| Molecular Weight | 354.35800 |
| Flash Point | 498ºC |
| Exact Mass | 354.15400 |
| PSA | 158.90000 |
| Index of Refraction | 1.575 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |