[Glu2]-TRH
![[Glu2]-TRH Structure](https://image.chemsrc.com/caspic/090/85541-78-2.png)
[Glu2]-TRH structure
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Common Name | [Glu2]-TRH | ||
|---|---|---|---|---|
| CAS Number | 85541-78-2 | Molecular Weight | 354.35800 | |
| Density | 1.416g/cm3 | Boiling Point | 899.9ºC at 760 mmHg | |
| Molecular Formula | C15H22N4O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 498ºC | |
Use of [Glu2]-TRH(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | [Glu2]-TRH |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | (Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1]. |
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| Related Catalog | |
| In Vivo | (Glu2)-TRH (1-100 μmol/kg; 静脉注射) 剂量依赖性地减弱 TRH 诱导的兴奋作用[1]。 (Glu2)-TRH (10 μmol/kg; 静脉注射) 在戊巴比妥 (60 mg/kg; 腹腔) 前 10 分钟给药，与载体治疗组相比，睡眠时间减少了大约 20%[1]。 Animal Model: Male Swiss-Webster mice (30 g)[1] Dosage: 1, 2, 5, 10, 15, 25, 50, 100 μmol/kg Administration: IV; 10 min before Pentobarbital (60 mg/kg, i.p.) Result: Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.416g/cm3 |
|---|---|
| Boiling Point | 899.9ºC at 760 mmHg |
| Molecular Formula | C15H22N4O6 |
| Molecular Weight | 354.35800 |
| Flash Point | 498ºC |
| Exact Mass | 354.15400 |
| PSA | 158.90000 |
| Index of Refraction | 1.575 |
| InChIKey | HYZBGWLLSXSYLX-GUBZILKMSA-N |
| SMILES | NC(=O)C1CCCN1C(=O)C(CCC(=O)O)NC(=O)C1CCC(=O)N1 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Fertilization promoting peptide--a possible regulator of sperm function in vivo.
Vitam. Horm. 63 , 1-28, (2001) Fertilization promoting peptide (FPP), a tripeptide related to thyrotrophin releasing hormone (TRH), is found in seminal plasma. Recent evidence obtained in vitro suggests that FPP may play an importa... |
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Fertilization promoting peptide and adenosine, acting as first messengers, regulate cAMP production and consequent protein tyrosine phosphorylation in a capacitation-dependent manner.
Mol. Reprod. Dev. 57(4) , 384-92, (2000) Fertilization promoting peptide (FPP) and adenosine have been shown to act as first messengers, regulating availability of the second messenger cAMP by initially stimulating cAMP production in uncapac... |
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In vitro neuroprotection against glutamate-induced toxicity by pGlu-Glu-Pro-NH(2) (EEP).
Peptides 22(12) , 2091-7, (2001) EEP is a tripeptide structurally similar to thyrotropin releasing hormone (TRH) and, like TRH, it is found in the mammalian brain. TRH has been found to increase in brain regions after seizures and to... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Inhibition of pig brain TRH-DE at 1 mM using Glp-His-ProAMC as substrate by DPP-4-bas...
Source: ChEMBL
Target: Thyrotropin releasing hormone degrading enzyme
External Id: CHEMBL3880448
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Name: Inhibition of pig brain TRH-DE using Glp-His-ProAMC as substrate by DPP-4-based conti...
Source: ChEMBL
Target: Thyrotropin releasing hormone degrading enzyme
External Id: CHEMBL3880449
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Name: Substrate activity at pig brain TRH-DE assessed as rate of hydrolysis at 1 mM incubat...
Source: ChEMBL
Target: Thyrotropin releasing hormone degrading enzyme
External Id: CHEMBL3880451
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| GLP-GLU-PRO-NH2 |
| PE-E-P-NH2 |
| fertilization promoting peptide |
| FPP |
| (GLU2)-TRH |
| PYR-GLU-PRO-NH2 |
| PGLU-GLU-PRO AMIDE |
| PYROGLU-GLU-PRO AMIDE |
| FPP,Fertilization-ProMoting Peptide |
| pyroglutamyl-glutamyl-prolineamide |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does [Glu2]-TRH have? |
| A: English synonyms of [Glu2]-TRH: GLP-GLU-PRO-NH2, PE-E-P-NH2, fertilization promoting peptide, FPP, (GLU2)-TRH, PYR-GLU-PRO-NH2, PGLU-GLU-PRO AMIDE, PYROGLU-GLU-PRO AMIDE, FPP,Fertilization-ProMoting Peptide, pyroglutamyl-glutamyl-prolineamide. |
| Q: What is the polar surface area (PSA) of [Glu2]-TRH? |
| A: Polar surface area (PSA) of [Glu2]-TRH is 158.90000. |
| Q: What is the molecular formula of [Glu2]-TRH? |
| A: Molecular formula of [Glu2]-TRH is C15H22N4O6. |
| Q: What Chinese synonyms does [Glu2]-TRH have? |
| A: Chinese synonyms of [Glu2]-TRH: (GLU2)-TRH. |
| Q: What is the molecular weight of [Glu2]-TRH? |
| A: Molecular weight of [Glu2]-TRH is 354.35800. |
| Q: What are the uses of [Glu2]-TRH? |
| A: Main uses of [Glu2]-TRH: (Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1]. |
| Q: What is the boiling point of [Glu2]-TRH? |
| A: Boiling point of [Glu2]-TRH is 899.9ºC at 760 mmHg. |
| Q: What is the Chinese name of 85541-78-2? |
| A: Chinese name of 85541-78-2 is GLP-GLU-PRO-NH2: GLP-EP-NH2. |
| Q: What is the English name of [Glu2]-TRH? |
| A: The English name of [Glu2]-TRH is [Glu2]-TRH. |
| Q: What is the SMILES notation of [Glu2]-TRH? |
| A: SMILES notation of [Glu2]-TRH is NC(=O)C1CCCN1C(=O)C(CCC(=O)O)NC(=O)C1CCC(=O)N1. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Dayang Chem (Hangzhou) Co., Ltd. |