127633-71-0

127633-71-0 structure

Name: (β-Ala8)-Neurokinin A (4-10)
Chemical Name: 3-amino-4-[[1-[[1-[[1-[[3-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
CAS Number: 127633-71-0
Molecular Formula: C₃₅H₅₆N₈O₉S
Molecular Weight: 764.93200
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2018-12-31 15:24:03
Modify Date: 2024-01-01 18:12:00
(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist[1].

Name	3-amino-4-[[1-[[1-[[1-[[3-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Synonyms	Asp-Ala-Phe-Val-\|A-Ala-Leu-Met-NH2 [Ala5,\|A-Ala8]-\|A-Neurokinin Fragment 4-10

Description	(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vivo	(β-Ala8)-Neurokinin A (4-10) (2 μg/kg; i.v.) increases colonic tone in conscious female dogs[2].
References	[1]. C A Maggi, et al. In vivo pharmacology of [beta Ala8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist. Eur J Pharmacol. 1990 Feb 20;177(1-2):81-6. [2]. G Basilisco, et al. A selective NK-2 antagonist blocks the increase of canine colonic tone and ileal contractions induced by the NK-2 selective receptor agonist, [beta Ala8] neurokinin A-(4-10). Aliment Pharmacol Ther. 1994 Oct;8(5):527-33.

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