(β-Ala8)-Neurokinin A (4-10)

Modify Date: 2024-01-01 18:12:00

(β-Ala8)-Neurokinin A (4-10) Structure
(β-Ala8)-Neurokinin A (4-10) structure
Common Name (β-Ala8)-Neurokinin A (4-10)
CAS Number 127633-71-0 Molecular Weight 764.93200
Density N/A Boiling Point N/A
Molecular Formula C35H56N8O9S Melting Point N/A
MSDS USA Flash Point N/A

 Use of (β-Ala8)-Neurokinin A (4-10)


(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist[1].

 Names

Name 3-amino-4-[[1-[[1-[[1-[[3-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-3-oxopropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Synonym More Synonyms

 (β-Ala8)-Neurokinin A (4-10) Biological Activity

Description (β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist[1].
Related Catalog
In Vivo (β-Ala8)-Neurokinin A (4-10) (2 μg/kg; i.v.) increases colonic tone in conscious female dogs[2].
References

[1]. C A Maggi, et al. In vivo pharmacology of [beta Ala8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist. Eur J Pharmacol. 1990 Feb 20;177(1-2):81-6.  

[2]. G Basilisco, et al. A selective NK-2 antagonist blocks the increase of canine colonic tone and ileal contractions induced by the NK-2 selective receptor agonist, [beta Ala8] neurokinin A-(4-10). Aliment Pharmacol Ther. 1994 Oct;8(5):527-33.  

 Chemical & Physical Properties

Molecular Formula C35H56N8O9S
Molecular Weight 764.93200
Exact Mass 764.38900
PSA 306.31000
LogP 2.66780

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles2

More Articles
Analogs of neurokinin A(4-10) afford protection against gastroduodenal ulcers in rats.

Peptides 11 , 293-297, (1990)

We have developed a novel series of peptides, related to the NKA(4-10) sequence, in which substitution of selected amino acids determined variations in the affinity for the TK receptor subtypes. Subcu...

Tachykinin-induced responses via neurokinin-1 and -3 receptors in hamster submandibular ganglion neurones.

Arch. Oral Biol. 44 , 455-463, (1999)

Both substance P and neurokinin A are known as neurotransmitters of the submandibular ganglion cell. In this study, the effects of neurokinin (NK) receptor-subtype agonists on hamster submandibular ga...

 Synonyms

Asp-Ala-Phe-Val-|A-Ala-Leu-Met-NH2
[Ala5,|A-Ala8]-|A-Neurokinin Fragment 4-10