190274-53-4
190274-53-4 structure
- Name: Calpain Inhibitor VI
- Chemical Name: 2-[(4-fluorophenyl)sulfonylamino]-3-methyl-N-(4-methyl-1-oxopentan-2-yl)butanamide
- CAS Number: 190274-53-4
- Molecular Formula: C17H25FN2O4S
- Molecular Weight: 372.455
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
- Create Date: 2018-12-26 12:20:49
- Modify Date: 2024-01-06 20:23:39
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Calpain Inhibitor VI (SJA6017) is a synthesized peptide aldehyde inhibitor of calpain. Calpain Inhibitor VI inhibits purified m-calpain with the IC50 of 80 nM. Calpain Inhibitor VI can be used for the research of cataract[1].
| Name | 2-[(4-fluorophenyl)sulfonylamino]-3-methyl-N-(4-methyl-1-oxopentan-2-yl)butanamide |
|---|---|
| Synonyms |
N-[(4-Fluorophenyl)sulfonyl]-N-[(2S)-4-methyl-1-oxo-2-pentanyl]-L-valinamide
N-((4-Fluorophenyl)sulfonyl)-L-valyl-L-leucinal IN1503 Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)- (2R)-2-[(4-fluorophenyl)sulfonylamino]-3-methyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]butanamide calpain inhibitor VI 4-fluorophenylsulfonyl-Val-Leu-CHO (1'S,2S)-2-(4-fluorobenzenesulfonylamino)-N-(1-formyl-3-methylbutyl)-3-methylbutyramide |
| Description | Calpain Inhibitor VI (SJA6017) is a synthesized peptide aldehyde inhibitor of calpain. Calpain Inhibitor VI inhibits purified m-calpain with the IC50 of 80 nM. Calpain Inhibitor VI can be used for the research of cataract[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C17H25FN2O4S |
| Molecular Weight | 372.455 |
| Exact Mass | 372.151917 |
| PSA | 100.72000 |
| LogP | 3.21 |
| Index of Refraction | 1.512 |
|
~60%
190274-53-4 |
| Literature: Senju Pharmaceutical Co., Ltd. Patent: EP1557407 A1, 2005 ; Location in patent: Page/Page column 6 ; |
|
~74%
190274-53-4 |
| Literature: Payne, Richard J.; Brown, Karina M.; Coxon, James M.; Morton, James D.; Lee, Hannah Yun-Young; Abell, Andrew D. Australian Journal of Chemistry, 2004 , vol. 57, # 9 p. 877 - 884 |
|
~%
190274-53-4 |
| Literature: Inoue, Jun; Nakamura, Masayuki; Cui, Ying-She; Sakai, Yusuke; Sakai, Osamu; Hill, Jeanette R.; Wang, Kevin K. W.; Yuen, Po-Wai Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 868 - 871 |
|
~%
190274-53-4 |
| Literature: Inoue, Jun; Nakamura, Masayuki; Cui, Ying-She; Sakai, Yusuke; Sakai, Osamu; Hill, Jeanette R.; Wang, Kevin K. W.; Yuen, Po-Wai Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 868 - 871 |
|
~%
190274-53-4 |
| Literature: Inoue, Jun; Nakamura, Masayuki; Cui, Ying-She; Sakai, Yusuke; Sakai, Osamu; Hill, Jeanette R.; Wang, Kevin K. W.; Yuen, Po-Wai Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 868 - 871 |
|
~%
190274-53-4 |
| Literature: Inoue, Jun; Nakamura, Masayuki; Cui, Ying-She; Sakai, Yusuke; Sakai, Osamu; Hill, Jeanette R.; Wang, Kevin K. W.; Yuen, Po-Wai Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 868 - 871 |
|
~%
190274-53-4 |
| Literature: Payne, Richard J.; Brown, Karina M.; Coxon, James M.; Morton, James D.; Lee, Hannah Yun-Young; Abell, Andrew D. Australian Journal of Chemistry, 2004 , vol. 57, # 9 p. 877 - 884 |
|
~%
190274-53-4 |
| Literature: Payne, Richard J.; Brown, Karina M.; Coxon, James M.; Morton, James D.; Lee, Hannah Yun-Young; Abell, Andrew D. Australian Journal of Chemistry, 2004 , vol. 57, # 9 p. 877 - 884 |
