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20123-80-2

20123-80-2 structure
20123-80-2 structure
  • Name: Calcium dobesilate
  • Chemical Name: calcium,2,5-dihydroxybenzenesulfonate
  • CAS Number: 20123-80-2
  • Molecular Formula: C12H10CaO10S2
  • Molecular Weight: 418.410
  • Catalog: API Circulatory system medication Peripheral vasodilator
  • Create Date: 2018-04-26 08:00:00
  • Modify Date: 2025-08-20 17:19:57
  • Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.
Name calcium,2,5-dihydroxybenzenesulfonate
Synonyms Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt (2:1)
calcium 2,5-dihydroxybenzenesulfonate
Calcium dobesilate
Nugatex
Dobesilat-Calciumsalz
Dobesilato calcico
Calcium Doxybensylate
calcium salt of 2,5-dihydroxybenzenesulfonic acid
Doxium
Calcii dobesilas
MFCD08457542
calcium 2,5-dihydroxy-phenylsulfonate
2,5-Dihydroxybenzenesulfonic acid calcium salt,205E,Calcium 2,5-dihydroxybenzenesulfonate
Dobesilate calcium
2,5-dihydroxybenzenesulfonic acid calcium salt
Calcium bis(2,5-dihydroxybenzenesulfonate)
Rasexinium
EINECS 243-531-5
Dexium
Toraxine
Description Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.
Related Catalog
References

[1]. Allain H, et al. Safety of calcium dobesilate in chronic venous disease, diabetic retinopathy and haemorrhoids. Drug Saf. 2004;27(9):649-60.
Molecular Formula C12H10CaO10S2
Molecular Weight 418.410
Exact Mass 417.934143
PSA 212.08000
LogP 2.16540
Storage condition room temp

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB6127000
CHEMICAL NAME :
Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt
CAS REGISTRY NUMBER :
20123-80-2
LAST UPDATED :
199512
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C12-H10-O10-S2.Ca
MOLECULAR WEIGHT :
418.42
WISWESSER LINE NOTATION :
WSO&R BQ EQ 2 &-CA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7061 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7549 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
876 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
775 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 30,415,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3509207
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
4979 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26
HS Code 2924299090
HS Code 2908999090
Summary 2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
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