101152-94-7
101152-94-7 structure
- Name: Milnacipran hydrochloride
- Chemical Name: Milnacipran Hydrochloride
- CAS Number: 101152-94-7
- Molecular Formula: C15H23ClN2O
- Molecular Weight: 282.809
- Catalog: analytical chemistry Standard standard material
- Create Date: 2018-03-08 08:00:00
- Modify Date: 2026-07-04 16:29:23
-
Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.Target: SNRIMilnacipran (Ixel, Savella, Dalcipran, Toledomin) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. It is not approved for the clinical treatment of major depressive disorder in the USA, but it is in other countries.Milnacipran inhibits the reuptake of serotonin and norepinephrine in an approximately 1:3 ratio, respectively; in practical use this means a relatively balanced action upon bothneurotransmitters. Increasing both neurotransmitters concentration simultaneously works synergistically to treat both depression and fibromyalgia. Milnacipran exerts no significant actions onH1, α1, D1, D2, and mACh receptors, as well as on benzodiazepine and opioid binding sites. Milnacipran is well absorbed after oral dosing and has a bioavailability of 85%. Meals do not have an influence on the rapidity and extent of absorption. Peak plasma concentrations are reached 2 hours after oral dosing. The elimination half-life of 8 hours is not increased by liver impairment and old age, but by significant renal disease. Milnacipran is conjugated to the inactive glucuronide and excreted in the urine as unchanged drug and conjugate. Only traces of active metabolites are found.
| Name | Milnacipran Hydrochloride |
|---|---|
| Synonyms |
F 2207, Midalcipran, Toledomin, (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecboxamide monohydrochloride
Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, hydrochloride (1:1) MIDALCIPRAN HYDROCHLORIDE Milnacipran-d5 HCl (and Enantiomer) Milnacipran HCl - Bio-X Milnacipran HCl rel-2α*-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1α*-cboxamide·hydrochloride Milnacipran Hydrochloride 1.0 mg/ml in Methanol (as free base) MFCD00901293 Milnacipran (hydrochloride) Milnacipran hydrochloride Serotonin and norinhrine reuptake inhibitor Midalcipran hydrochloride 2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecboxamide hydrochloride Milnacipran Hydrochloride Impurities RSYYMilnacipranhydrochloride (1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride (1:1) Milnacipran hydrochloride in acetonitrile 2-(aminomethyl)-n,n-diethyl-1-phenyl-cyclopropanecboxamidmonohydrochlori Chiral Reagents (1R,2S)-REL-2-(AMINOMETHYL)-N,N-DIMETHYL-1-PHENYLCYCLOPROPANECBOXAMIDE HYDROCHLORIDE 2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride (1:1) Milnacipran HCI Milnacipran hydrochloride, Serotonin and norinhrine reuptake inhibitor Midalcipran cis-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride rac Milnacipran Hydrochloride cis-(+-)-d MILNACIPRAN HYDROCHLORIDE Milnacipran Hydrochloride Tablets MIDALCIPRAN Milnacipran Hydrochloride (Subject to patent free) 1-Phenyl-1-(diethylaminocarbonyl)-2-(aminomethyl)cyclopropane hydrochloride Dalcipran (1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecboxamidehydrochloride Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, (1R,2S)-, hydrochloride (1:1) cis-(+-)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecboxamidemonohydr MilnacipranHydrochloride> (1R-2S)-Milnacipran hydrochloride Milnacipran hydrochloride, 10 mM in DMSO Minapram hydrochloride Milnacipran hydrochlorideQ: What is Milnacipran hydrochloride Q: What is the CAS Number of Milnacipran hydrochloride Q: What is the storage condition of Milnacipran hydrochloride Q: What e the applications of Milnacipran hydrochloride D5-Milnacipran HCl EINECS 200-659-6 (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride MLNACIPRAM HCL 1-phenyl-1-(diethylaminocbonyl)-2-(aminomethyl)cyclopropanehydrochloride Milancipran Hydrochloride Cyclopropanecboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, hydrochloride (1:1), (1R,2S)-rel (1R,2S)-REL-2-(AMINOMETHYL)-N,N-DIETHYL-1-PHENYLCYCLOPROPANECBOXAMIDE HYDROCHLORIDE UNII:RNZ43O5WW5 Milnacipran hydrochloride solution TOLEDOMIN (1R,2S)-rel-2(Amino-methyl)-N,N-diethyl-1-phenyl-cyclopropanecboxamide, Monohydrochloride |
| Description | Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.Target: SNRIMilnacipran (Ixel, Savella, Dalcipran, Toledomin) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. It is not approved for the clinical treatment of major depressive disorder in the USA, but it is in other countries.Milnacipran inhibits the reuptake of serotonin and norepinephrine in an approximately 1:3 ratio, respectively; in practical use this means a relatively balanced action upon bothneurotransmitters. Increasing both neurotransmitters concentration simultaneously works synergistically to treat both depression and fibromyalgia. Milnacipran exerts no significant actions onH1, α1, D1, D2, and mACh receptors, as well as on benzodiazepine and opioid binding sites. Milnacipran is well absorbed after oral dosing and has a bioavailability of 85%. Meals do not have an influence on the rapidity and extent of absorption. Peak plasma concentrations are reached 2 hours after oral dosing. The elimination half-life of 8 hours is not increased by liver impairment and old age, but by significant renal disease. Milnacipran is conjugated to the inactive glucuronide and excreted in the urine as unchanged drug and conjugate. Only traces of active metabolites are found. |
|---|---|
| Related Catalog | |
| References |
| Boiling Point | 393ºC at 760 mmHg |
|---|---|
| Melting Point | 179-181ºC |
| Molecular Formula | C15H23ClN2O |
| Molecular Weight | 282.809 |
| Exact Mass | 282.149902 |
| PSA | 46.33000 |
| LogP | 3.27370 |
| Vapour Pressure | 1.66E-07mmHg at 25°C |
| Storage condition | 2-8°C |
| Water Solubility | H2O: 19 mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| RTECS | GZ1014010 |
| Flash Point(F) | 48.2 °F |
| Flash Point(C) | 9 °C |