20004-62-0

20004-62-0 structure

Name: Resistomycin
Chemical Name: resistomycin
CAS Number: 20004-62-0
Molecular Formula: C₂₂H₁₆O₆
Molecular Weight: 376.35900
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-04-23 05:58:56
Modify Date: 2024-01-05 12:18:26
Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis[1][2][3][4].

Name	resistomycin
Synonyms	3,5,7,10-Tetrahydroxy-1,1,9-trimethyl-2H-benzo[cd]pyrene-2,6(1H)-dione A 3733A Itamycin 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1H-benzo[cd]pyrene-2,6-dione 2H-Benzo(cd)pyrene-2,6(1H)-dione,3,5,7,10-tetrahydroxy-1,1,9-trimethyl Geliomycin Antibiotic A 3733a 3,5,7,10-Tetrahydroxy-1,1,9-trimethyl-1H-benzo[cd]pyren-2,6-dion Croceomycin

Description	Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation[1]. Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance[1]. Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells[1]. Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo[3].

Molecular Formula	C₂₂H₁₆O₆
Molecular Weight	376.35900
Exact Mass	376.09500
PSA	115.06000
LogP	3.65590

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ6350000

CHEMICAL NAME :: 2H-Benzo(cd)pyrene-2,6(1H)-dione, 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-

CAS REGISTRY NUMBER :: 20004-62-0

BEILSTEIN REFERENCE NO. :: 2187224

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H16-O6

MOLECULAR WEIGHT :: 376.38

WISWESSER LINE NOTATION :: L C6666 B6 3ABC S GV IV RHJ EQ KQ M1 OQ R1 R1 SQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,354,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,351,1980 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20750 ug/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application

REFERENCE :: JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 71,539,1983

HS Code	2914400090

22852-03-5

~87%

20004-62-0

Literature: Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

96328-31-3

20004-62-0

Literature: Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

96328-34-6

20004-62-0

Literature: Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

96328-32-4

20004-62-0

Literature: Kelly; Ghoshal Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 3879 - 3884

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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