512-64-1
512-64-1 structure
- Name: Echinomycin
- Chemical Name: quinomycin a
- CAS Number: 512-64-1
- Molecular Formula: C51H64N12O12S2
- Molecular Weight: 1101.26000
- Catalog: Research Areas Cancer
- Create Date: 2018-03-06 08:00:00
- Modify Date: 2025-08-25 18:11:08
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Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2].
| Name | quinomycin a |
|---|---|
| Synonyms |
echinomycin
quinomycin-A |
| Description | Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Echinomycin (0-10 nM; 16 hours; U251 cells) treatment significantly inhibits hypoxia-induced VEGF mRNA expression in a dose-dependent fashion. Echinomycin very potently inhibits hypoxic induction of luciferase expression in U251-HRE in a dose-dependent fashion with an EC50 of 1.2 nM[1]. RT-PCR[1] Cell Line: U251 cells Concentration: 0 nM, 0.625 nM, 1.25 nM, 5 nM, 10 nM Incubation Time: 16 hours Result: Significantly inhibited VEGF mRNA expression induced by hypoxia in a dose-dependent fashion. |
| In Vivo | Echinomycin (10 μg/kg; intravenous injection; for 40 days; NOD-SCID mice) treatment efficiently eradicates mouse lymphoma and serially transplantable human acute myeloid leukemia (AML) in xenogeneic model by preferential elimination of cancer stem cells (CSCs). HIF1α maintains mouse lymphoma CSCs by repressing a negative feedback loop in the Notch pathway[2]. Animal Model: NOD-SCID mice received 1.8Gy of irradiation and i.v. injection with peripheral blood cells from patients AML-71 and AML-150[2] Dosage: 10 μg/kg Administration: Intravenous injection; for 40 days Result: Efficiently eradicated mouse lymphoma and serially transplantable human AML in xenogeneic model by preferential elimination of CSCs. |
| References |
| Density | 1.41 g/cm3 |
|---|---|
| Boiling Point | 1427.2ºC at 760 mmHg |
| Molecular Formula | C51H64N12O12S2 |
| Molecular Weight | 1101.26000 |
| Flash Point | 817ºC |
| Exact Mass | 1100.42000 |
| PSA | 352.40000 |
| LogP | 1.82630 |
| Index of Refraction | 1.536 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331-H361 |
| Precautionary Statements | P261-P280-P301 + P310-P311 |
| Hazard Codes | T: Toxic; |
| Risk Phrases | R46 |
| Safety Phrases | 53-36/37/39-45 |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | JW5250000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |