131986-45-3

131986-45-3 structure

Name: Xanomeline
Chemical Name: xanomeline
CAS Number: 131986-45-3
Molecular Formula: C₁₄H₂₃N₃OS
Molecular Weight: 281.41700
Catalog: API Respiratory medication Asthma
Create Date: 2018-09-23 06:22:00
Modify Date: 2024-01-02 07:51:51
Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia[1][2].

Name	xanomeline
Synonyms	3-hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole

Description	Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	M1/M4[1][2]
In Vitro	Xanomeline (0.1~10 μM; CNS4U) shows an overall increase in the mean firing rate. Xanomeline shows the M1 receptor is functional in hiPSC derived neurons. Xanomeline (＞1 μM) has a prolonged engagement with the receptor and produces a persistent receptor activation leading to a sustained suppression of the M-current[1].
In Vivo	Xanomeline (0.5~3 mg/kg; s.c.; 1~3 hours) induces salivation and vomiting in some monkeys[3]. Xanomeline shows functional dopamine antagonism and an antipsychotic-like profile.Xanomeline inhibits D-amphetamine- and (−)-apomorphine-induced behavior and do not cause extrapyramidal side effects[3]. Animal Model: Male Cebus apella monkeys Dosage: 0.5~3 mg/kg Administration: S.c.; 1~3 hours Result: Induced salivation and vomiting in some monkeys.
References	[1]. Kreir M, et al. Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons. Eur J Pharmacol. 2019;858:172474 [2]. Shekhar A, et al. Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry. 2008;165(8):1033-1039. [3]. Andersen MB, et al. The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys. Neuropsychopharmacology. 2003;28(6):1168-1175.

Density	1.101 g/cm3
Boiling Point	397ºC at 760 mmHg
Molecular Formula	C₁₄H₂₃N₃OS
Molecular Weight	281.41700
Flash Point	193.9ºC
Exact Mass	281.15600
PSA	66.49000
LogP	3.15400
Appearance	off-white
Vapour Pressure	1.64E-06mmHg at 25°C
Index of Refraction	1.537
Storage condition	2-8°C
Water Solubility	H2O: soluble10mg/mL, clear (warmed)

HS Code	2934999090

Precursor 2
131988-19-7 111-27-3
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%