111786-07-3
111786-07-3 structure
- Name: RGW2938
- Chemical Name: 3-methyl-6-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-1,4-dihydroquinazolin-2-one
- CAS Number: 111786-07-3
- Molecular Formula: C13H13N4O2
- Molecular Weight: 257.27
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2018-06-05 08:00:00
- Modify Date: 2024-01-02 22:26:08
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RGW2938 is a phosphodiesterase inhibitor.
| Name | 3-methyl-6-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-1,4-dihydroquinazolin-2-one |
|---|---|
| Synonyms |
Prinoxodanum
RGW 2938 3,4-Dihydro-3-methyl-6-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2(1H)-quinazolinone Prinoxodanum [INN-Latin] Prinoxodano [INN-Spanish] PRINOXODAN 2(1H)-Quinazolinone,3,4-dihydro-3-methyl-6-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl) Prinoxodano RGW2938 |
| Description | RGW2938 is a phosphodiesterase inhibitor. |
|---|---|
| Related Catalog | |
| Target |
Phosphodiesterase[1] |
| In Vitro | RGW2938 is an orally effective positive inotropic/vasodilator agent. RGW2938 is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vitro in isolated guinea pig hearts; in the latter, RGW2938 5 nmol-5 μmol increases contractility in a dose-related fashion[2]. |
| In Vivo | RGW2938 is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vivo in anesthetized and conscious dogs. RGW2938 30-300 μg/kg administered intravenously (i.v.) to anesthetized dogs increases contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. Heart rate (HR) is only slightly increased, and aortic flow is not appreciably altered. A single oral dose of RGW2938 0.3 mg/kg administered to conscious chronically instrumented dogs produces a marked and sustained increase in contractility 15-240 min after treatment while only slightly increasing HR. The effects of RGW2938 30-300 μg/kg, i.v. are studied in a mecamylamine-propranolol-induced model of heart failure. RGW2938 effectively reverses the drug-induced heart failure by increasing myocardial contractility and decreasing arterial pressure while only slightly affecting HR[2]. |
| References |
| Density | 1.47g/cm3 |
|---|---|
| Molecular Formula | C13H13N4O2 |
| Molecular Weight | 257.27 |
| PSA | 73.80000 |
| LogP | 1.11830 |
| Index of Refraction | 1.724 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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