910297-51-7

910297-51-7 structure

Name: N-Deshydroxyethyl Dasatinib
Chemical Name: N-(2-chloro-6-methylphenyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide
CAS Number: 910297-51-7
Molecular Formula: C₂₀H₂₂ClN₇OS
Molecular Weight: 443.95300
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2018-12-12 20:07:08
Modify Date: 2024-01-02 15:51:06
Target Protein-binding moiety 8 is a compound binding to BCR-ABL, and used for inhibiting BCR-ABL activity.

Name	N-(2-chloro-6-methylphenyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide
Synonyms	N-(2-CHLORO-6-METHYLPHENYL)-2-[[2-METHYL-6-(PIPERAZIN-1-YL)-PYRIMIDIN-4-YL]AMINO]-5-THIAZOLECARBOXAMIDE Dasatinib metabolite M4 N-(2-chloro-6-methylphenyl)-2-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-5-carboxamide N-(2-chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolecarboxamide N-Deshydroxyethyl Dasatinib Dasatinib Impurity 6 Target Protein-binding moiety 8

Description	Target Protein-binding moiety 8 is a compound binding to BCR-ABL, and used for inhibiting BCR-ABL activity.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl Signaling Pathways >> PROTAC >> PROTAC Research Areas >> Cancer
Target	BCR-ABL[1]
In Vitro	Target Protein-binding moiety 8 (Compound 8) is a compound binding to BCR-ABL, and used for inhibiting BCR-ABL activity.
References	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Density	1.404g/cm3
Melting Point	>300ºC
Molecular Formula	C₂₀H₂₂ClN₇OS
Molecular Weight	443.95300
Exact Mass	443.13000
PSA	123.31000
LogP	4.14860
Index of Refraction	1.69

110-85-0

302964-08-5

~20%

910297-51-7

910297-61-9

Literature: Arora, Vinod Kumar; Christopher, Lisa Joy; Cui, Donghui; Li, Wenying Patent: US2006/211705 A1, 2006 ; Location in patent: Page/Page column 28 ;

110-85-0

302964-08-5

~79%

910297-51-7

Literature: Veach, Darren R.; Namavari, Mohammad; Pillarsetty, Nagavarakishore; Santos, Elmer B.; Beresten-Kochetkov, Tatiana; Lambek, Caryl; Punzalan, Blesida J.; Antczak, Christophe; Smith-Jones, Peter M.; Djaballah, Hakim; Clarkson, Bayard; Larson, Steven M. Journal of Medicinal Chemistry, 2007 , vol. 50, # 23 p. 5853 - 5857

Precursor 2
110-85-0 302964-08-5
DownStream 1
910297-62-0

910297-51-7	1189998-96-6
1159977-13-5	1263379-04-9
4617-82-7	302964-08-5
158729-32-9	152811-55-7
158729-30-7	58068-80-7