910297-51-7

• 常用中文名：N-脱羟乙基达沙替尼
• 常用英文名：N-Deshydroxyethyl Dasatinib
• CAS号：910297-51-7
• 分子式：C₂₀H₂₂ClN₇OS
• 分子量：443.95300
• 相关类别： 信号通路 蛋白裂解靶向嵌合体 PROTAC
• 发布时间：2018-12-12 20:07:08
• 更新时间：2026-07-06 17:03:33
• Target Protein-binding moiety 8 是一种能够与 BCR-ABL 结合的结构,用于抑制 BCR-ABL 的活性。

名称

• 中文名: N-脱羟乙基达沙替尼
• 英文名: N-(2-chloro-6-methylphenyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide
• 中文别名: 达沙替尼N-去羟乙基(达沙替尼杂质); 达沙替尼杂质01; N-去羟乙基达沙替尼,10 MM DMSO 溶液; 达沙替尼N-去羟乙基杂质; A达沙替尼杂质3; N-去羟乙基达沙替尼; N-脱羟基乙基达沙替尼; N-(2-氯-6-甲基苯基)-2-((2-甲基-6-(哌嗪-1-基)嘧啶-4-基)氨基)噻唑-5-甲酰胺; 达沙替尼杂质A; 达沙替尼N-去羟乙基; 达沙替尼N-脱羟乙基杂质; N-(2-氯-6-甲基苯基)-2-{[2-甲基-6-(1-哌嗪基)-4-嘧啶基]氨基}-1,3-噻唑-5-甲酰胺
• 英文别名: N-Deshydroxyethyl Dasatinib, 10 mM in DMSO; N-(2-CHLORO-6-METHYLPHENYL)-2-[[2-METHYL-6-(PIPERAZIN-1-YL)-PYRIMIDIN-4-YL]AMINO]-5-THIAZOLECARBOXAMIDE; dasatinib N-Deshydroxyethyl Imp; N-Deshydroxyethyl Dasatinib/N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl] amino]-5-thiazolecboxamide; Dasatinib N-Deshydroxyethyl Impurity; N-Deshydroxyethyl Dasatinib (Dasatinib Impurity); N-(2-chloro-6-methylphenyl)-2-((2-methyl-6; N-(2-chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolecarboxamide; N-(2-chloro-6-methylphenyl)-2-[(2-methyl-6-piperazin-1-ylpyrimidin-4-yl)amino]-1,3-thiazole-5-cboxamide; Dasatinib metabolite M4; N-Deshydroxyethyl BMS-354825; Dasatinib Impurity 6; N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolecboxamide; 5-Thiazolecboxamide, N-(2-chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]; Dasatinib monohydrate B; N-(2-CHLORO-6-METHYLPHENYL)-2-{[2-METHYL-6-(PIPERAZIN-1-YL)PYRIMIDIN-4-YL]AMINO}-1,3-THIAZOLE-5-CB; Dasatinib impurity 3/N-Deshydroxyethyl Dasatinib/N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl] amino]-5-thiazolecboxamide; Dasatinib RC B; Target Protein-binding moiety 8; Dasatinib Impurity A; M4 BMS582691; Dasatinib Impurity01; N-(2-chloro-6-methylphenyl)-2-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-5-carboxamide

物化性质

• 密度: 1.404g/cm3
• 熔点: >300ºC
• 分子式: C₂₀H₂₂ClN₇OS
• 分子量: 443.95300
• 精确质量: 443.13000
• PSA: 123.31000
• LogP: 4.14860
• 外观性状: 固体
• 折射率: 1.69
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Target Protein-binding moiety 8 是一种能够与 BCR-ABL 结合的结构,用于抑制 BCR-ABL 的活性。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> BCR-ABL
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
  研究领域 >> 癌症
• 靶点:

  BCR-ABL[1]

• 体外研究: 靶蛋白结合部分8(化合物8)是与BCR-ABL结合的化合物,用于抑制BCR-ABL活性。
• 参考文献:

  [1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

合成路线

110-85-0 302964-08-5 ~20% 910297-51-7 910297-61-9

文献：Arora, Vinod Kumar; Christopher, Lisa Joy; Cui, Donghui; Li, Wenying Patent: US2006/211705 A1, 2006 ; Location in patent: Page/Page column 28 ;

110-85-0 302964-08-5 ~79% 910297-51-7

文献：Veach, Darren R.; Namavari, Mohammad; Pillarsetty, Nagavarakishore; Santos, Elmer B.; Beresten-Kochetkov, Tatiana; Lambek, Caryl; Punzalan, Blesida J.; Antczak, Christophe; Smith-Jones, Peter M.; Djaballah, Hakim; Clarkson, Bayard; Larson, Steven M. Journal of Medicinal Chemistry, 2007 , vol. 50, # 23 p. 5853 - 5857

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910297-62-0