Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzenebutanoic acid, a,2-diamino-3-hydroxy-g-oxo-
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484-78-6

484-78-6 structure

Name: 3-hydroxy-DL-Kynurenine
Chemical Name: 3-hydroxykynurenine
CAS Number: 484-78-6
Molecular Formula: C₁₀H₁₂N₂O₄
Molecular Weight: 224.21300
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-11-21 11:04:21
Modify Date: 2024-01-08 13:24:15
3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1].

Name	3-hydroxykynurenine
Synonyms	rac 3-Hydroxy Kynurenine Benzenebutanoic acid, a,2-diamino-3-hydroxy-g-oxo-

Description	3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
In Vitro	3-Hydroxykynurenine-induced neuronal cell death shows several features of apoptosis[1]. 3-Hydroxykynurenine is a metabolic intermediate of the kynurenine pathway, the major metabolic pathway of tryptophan (Trp)[1]. 3-Hydroxykynurenine acts as an endogenous neurotoxin in the brain under pathological conditions[1]. 3-Hydroxykynurenine (20-100 μM) significantly inhibits CD4+ T-cell proliferation in a dose-dependent manner with IC50 of approximately 70 μM[2]. 3-Hydroxykynurenine (20-100 μM) induces significant CD4+ T-cell-mediated cell death in a dose-dependent manner[2]. Cell Proliferation Assay[2] Cell Line: CD3/CD28 bead-stimulated CD4+ T cells Concentration: 0, 20, 40, 60, 80, and 100 μM Incubation Time: 72 hours Result: Significantly inhibited CD4+ T-cell proliferation in a dose-dependent manner with an IC50 of approximately 70 μM.
In Vivo	3-Hydroxykynurenine administration (560 mg/kg IP on a daily basis on days 1 to 7, days 7 to 14, or days 1 to 14) results in significant prolongation of graft survival whether administered between days 1 to 7, days 7 to 14, or days 1 to 14[2]. Animal Model: BALB/c (H2d) mice[2] Dosage: 560 mg/kg Administration: IP injection Result: There was significant prolongation of graft survival in all treatment groups in comparison to the controls.
References	[1]. S Okuda, et al. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem. 1998 Jan;70(1):299-307. [2]. Sarah S Zaher,et al. 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival. Invest Ophthalmol Vis Sci. 2011 Apr 22;52(5):2640-8.

Density	1.461g/cm3
Boiling Point	519.3ºC at 760mmHg
Molecular Formula	C₁₀H₁₂N₂O₄
Molecular Weight	224.21300
Flash Point	267.9ºC
Exact Mass	224.08000
PSA	126.64000
LogP	1.24060
Vapour Pressure	1.49E-12mmHg at 25°C
Index of Refraction	1.635
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY6475000

CHEMICAL NAME :: Alanine, 3-(3-hydroxyanthraniloyl)-

CAS REGISTRY NUMBER :: 484-78-6

LAST UPDATED :: 198910

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H12-N2-O4

MOLECULAR WEIGHT :: 224.24

WISWESSER LINE NOTATION :: ZR BQ FV1YZVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 10 mg/L

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 222,484,1969 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

HS Code	2922509090

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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