Name | 3-hydroxykynurenine |
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Synonyms |
rac 3-Hydroxy Kynurenine
Benzenebutanoic acid, a,2-diamino-3-hydroxy-g-oxo- |
Description | 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1]. |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
In Vitro | 3-Hydroxykynurenine-induced neuronal cell death shows several features of apoptosis[1]. 3-Hydroxykynurenine is a metabolic intermediate of the kynurenine pathway, the major metabolic pathway of tryptophan (Trp)[1]. 3-Hydroxykynurenine acts as an endogenous neurotoxin in the brain under pathological conditions[1]. 3-Hydroxykynurenine (20-100 μM) significantly inhibits CD4+ T-cell proliferation in a dose-dependent manner with IC50 of approximately 70 μM[2]. 3-Hydroxykynurenine (20-100 μM) induces significant CD4+ T-cell-mediated cell death in a dose-dependent manner[2]. Cell Proliferation Assay[2] Cell Line: CD3/CD28 bead-stimulated CD4+ T cells Concentration: 0, 20, 40, 60, 80, and 100 μM Incubation Time: 72 hours Result: Significantly inhibited CD4+ T-cell proliferation in a dose-dependent manner with an IC50 of approximately 70 μM. |
In Vivo | 3-Hydroxykynurenine administration (560 mg/kg IP on a daily basis on days 1 to 7, days 7 to 14, or days 1 to 14) results in significant prolongation of graft survival whether administered between days 1 to 7, days 7 to 14, or days 1 to 14[2]. Animal Model: BALB/c (H2d) mice[2] Dosage: 560 mg/kg Administration: IP injection Result: There was significant prolongation of graft survival in all treatment groups in comparison to the controls. |
References |
Density | 1.461g/cm3 |
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Boiling Point | 519.3ºC at 760mmHg |
Molecular Formula | C10H12N2O4 |
Molecular Weight | 224.21300 |
Flash Point | 267.9ºC |
Exact Mass | 224.08000 |
PSA | 126.64000 |
LogP | 1.24060 |
Vapour Pressure | 1.49E-12mmHg at 25°C |
Index of Refraction | 1.635 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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HS Code | 2922509090 |
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HS Code | 2922509090 |
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Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |