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6296-45-3

6296-45-3 structure
6296-45-3 structure

Name ethyl N-(2-chloroethyl)-N-nitrosocarbamate
Synonyms TL 154
2-Chloroethyl-N-nitrosourethane
Density 1.3g/cm3
Boiling Point 215.4ºC at 760 mmHg
Molecular Formula C5H9ClN2O3
Molecular Weight 180.59000
Flash Point 84.1ºC
Exact Mass 180.03000
PSA 58.97000
LogP 1.36510
Index of Refraction 1.493

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EZ2100000
CHEMICAL NAME :
Carbamic acid, (2-chloroethyl)nitroso-, ethyl ester
CAS REGISTRY NUMBER :
6296-45-3
BEILSTEIN REFERENCE NO. :
1781530
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C5-H9-Cl-N2-O3
MOLECULAR WEIGHT :
180.61
WISWESSER LINE NOTATION :
ON2OVM2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - alteration in gastric secretion
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
330 mg/m3/10M
TOXIC EFFECTS :
Behavioral - irritability Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6500 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - pleural effusion Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
330 mg/m3/10M
TOXIC EFFECTS :
Behavioral - irritability Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
330 mg/m3/10M
TOXIC EFFECTS :
Behavioral - irritability Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
500 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,175,1983

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6296-45-3 structure

6296-45-3

Literature: Lown, J. William; Joshua, Alummoottil V.; McLaughlin, Larry W. Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 798 - 805

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6296-45-3 structure

6296-45-3

Literature: Kamiya,S. Chemical and Pharmaceutical Bulletin, 1972 , vol. 20, p. 2497 - 2500
Precursor  2

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