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Product Name: AngiotensinIII,human,mouse
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13602-53-4

13602-53-4 structure

13602-53-4 structure

Name: Angiotensin III, human, mouse(Acetate)
Chemical Name: angiotensin iii, human
CAS Number: 13602-53-4
Molecular Formula: C₄₆H₆₆N₁₂O₉
Molecular Weight: 931.09100
Catalog: Biochemical Peptide
Create Date: 2018-02-22 08:00:00
Modify Date: 2024-01-02 11:42:09
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.

Name	angiotensin iii, human
Synonyms	angiotensin I-converting enzyme ACE INACTIVATOR ANGIOTENSIN I-CONVERTING ENZYME INACTIVATOR human AngIII angiotensin III CYANOAC-PHE-PHE-OH H-Arg-Val-Tyr-Ile-His-Pro-Phe-OH CYANOAC-PHE-PHE Angiotensin III, human, mouse

Description	Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Peptides Research Areas >> Cardiovascular Disease
Target	IC50: 0.648 nM (AT2R), 21.1 nM (AT1R)[1]
In Vitro	Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively[1].
In Vivo	Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (UNaV), fractional excretion of sodium (FENa), and fractional excretion of lithium (FELi) in SD rat[2]. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats[3].
References	[1]. Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303. [2]. Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95. [3]. Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48.

Density	1.39g/cm3
Molecular Formula	C₄₆H₆₆N₁₂O₉
Molecular Weight	931.09100
Exact Mass	930.50800
PSA	339.94000
LogP	3.71910
Index of Refraction	1.657
Storage condition	−20°C
Water Solubility	H2O: 1.0 mg/mL, clear, colorless

WGK Germany	3