Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Picolinic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: picolinic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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Contact: Anson
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 2-Picolinic acid
Price: ￥Inquiry/25kg
Purity: 99.0%
Stocking Period: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

98-98-6

98-98-6 structure

98-98-6 structure

Name: 2-Picolinic acid
Chemical Name: picolinic acid
CAS Number: 98-98-6
Molecular Formula: C₆H₅NO₂
Molecular Weight: 123.109
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-07-22 14:46:39
Modify Date: 2026-06-30 21:43:48
PCL 016 is a topical antiviral agent, which inhibits adenovirus replication in rabbit.

Name	picolinic acid
Synonyms	2- picolinate 2-PYRIDINECBOXYLIC ACID Pyridinecboxylic acid Picolinic acid, R 2-Picolinic acid ReagentPlus(R) 2-Cboxypyridine acidepicolique 2-PicoL 2-Pyridinecboxylic Picolinicacid(PCL016) 2-Picolinic acid ISO 9001：2015 REACH o-pyridinecboxylicacid Pyridine-cboxylique-2 Pyridine-2-cboxylicAcid> a-PICOLINIC ACID 2-PicolinicAcid inic acid 2-Pyridylcboxylic acid alpha-pyridinecboxylicacid 2-acid pyridine a-Pyridinecboxylic acid Pyridin-2-cbonsure 2-Picolinic acid,α-Picolinic acid, Pyridine-2-cboxylic acid Picolinic Acid 2 Sorafenib Impurity 18 PYRIDINE-2-CBOXYLIC ACID PYRIDINE-ALPHA-CBOXYLIC ACID Pyridine-2-cboxylic Picolinic aci 2-PICOLINIC ACID PICOLINIC ACID SOLUTION 2-Carboxypyridine Acide picolique PICOLINIC ACID Picolinic acid pyridine-2-carboxylic acid RECHEM AL BO 0209 Picolinsαure EINECS 202-719-7 2-Pyridine Cboxylic Acid TIMTEC-BB SBB004277 PICOLINIC(2-) ACID acidicolique 2-pyridinecarboxylic acid OEM Pyridine-2-cboxylic acid alpha-Pyridinecboxylic acid PCL 016 o-Pyridinecboxylic acid ALPHA-PICOLINIC ACID Picolinic acid, 2-Cboxypyridine Isoniazid Impurity G PICOLINIC ACID PYRIDINE-2-CBOXYLIC ACID MFCD00006293 picolinic acid，2-Pyridinecboxylic acid Picolonic acid 2-Pyridinecboxylic Aicd 2-Picolinic acid Vetec(TM) ade

Description	PCL 016 is a topical antiviral agent, which inhibits adenovirus replication in rabbit.
Related Catalog	Natural Products >> Others Research Areas >> Infection
Target	Human Endogenous Metabolite
In Vivo	Topical 1.5% PCL, 0.8% PCL, 0.369% PCL (pH7), 0.369% PCL (pH4) and 0.5% CDV are significantly more effective than the Control in reducing Ad Positive Cultures/Total (Days 1-14) and the Duration of Ad Shedding in the Ad5/NZW rabbit ocular model. Although not statistically significant, there appears to be a trend toward concentration-dependent efficacy of PCL 016 on the Duration of Ad Shedding. There is no apparent ocular toxicity associated with PCL 016 concentrations[1].
Animal Admin	Rabbits[1] 25 NZW rabbits are topically inoculated in both eyes, following corneal scarification, with 1.5 x 106 pfu/eye of Ad5. On day 1, the rabbits are divided into 6 topical treatment groups: I - 1.5% PCL 016 pH 7.0 (n=4); II - 0.8% PCL 016 pH 7.0 (n=4); III - 0.369% PCL 016 pH 7.0 (n=4); IV - 0.369% PCL 016 pH 4.0 (n=4); V - 0.5% Cidofovir (CDV) (n=4); VI - Control (saline) (n=5). PCL 016 and control rabbits are treated in both eyes 4 times daily for 7 days, while CDV rabbits are treated in both eyes twice daily for 7 days. All eyes are cultured for virus on days 0, 1, 3, 4, 5, 7, 9, 11, and 14[1].
References	[1]. E.G. Romanowski, et al. A Novel Topical Antiviral Agent, PCL–016 (Picolinic Acid), Inhibits Adenovirus Replication in the Ad5/NZW Rabbit Ocular Model. ARVO Annual Meeting Abstract. May 2005 Volume 46, Issue 13.

Density	1.3±0.1 g/cm3
Boiling Point	292.5±13.0 °C at 760 mmHg
Melting Point	139-142 °C(lit.)
Molecular Formula	C₆H₅NO₂
Molecular Weight	123.109
Flash Point	130.7±19.8 °C
Exact Mass	123.032028
PSA	50.19000
LogP	-0.10
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.571
Storage condition	Store at RT.
Water Solubility	887 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ7344000

CHEMICAL NAME :: Picolinic acid

CAS REGISTRY NUMBER :: 98-98-6

BEILSTEIN REFERENCE NO. :: 0109595

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H5-N-O2

MOLECULAR WEIGHT :: 123.12

WISWESSER LINE NOTATION :: T6NJ BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 17,2377,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 487 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 23,1343,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 562 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 295 gm/kg/8D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes

REFERENCE :: ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992- Volume(issue)/page/year: 47,25,1995

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn,Xi
Risk Phrases	R22:Harmful if swallowed. R36:Irritating to the eyes. R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36-S33-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TJ7344000
HS Code	29333999

Precursor 8
586-98-1 109-06-8 1121-60-4 524-38-9
55401-97-3 824-40-8 5029-67-4 201230-82-2
DownStream 9
1090815-16-9 10472-94-3 1094332-66-7 4282-47-7
53750-66-6 39627-98-0 5470-22-4 88912-25-8
3105-95-1

HS Code	29333999

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