345986-38-1
345986-38-1 structure
- Name: 2-(benzo[d]thiazol-2-yl)-2-(2-chloropyrimidin-4-yl)acetonitrile
- Chemical Name: 1,3-Benzothiazol-2-yl(2-chloro-4-pyrimidinyl)acetonitrile
- CAS Number: 345986-38-1
- Molecular Formula: C13H7ClN4S
- Molecular Weight: 286.74
- Catalog: Signaling Pathways MAPK/ERK Pathway JNK
- Create Date: 2017-02-12 05:57:15
- Modify Date: 2024-04-09 00:08:33
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JNK-IN-13 (compound 1) is a potent and selective JNK inhibitor with IC50s of 290 nM and 500 nM for JNK3 and JNK2, respectively[1].
| Name | 1,3-Benzothiazol-2-yl(2-chloro-4-pyrimidinyl)acetonitrile |
|---|---|
| Synonyms |
Benzothiazole,2-[(phenylmethyl)sulfonyl]
2-phenylmethanesulfonyl-benzothiazole 1,3-benzothiazol-2-yl(2-chloro-4-pyrimidinyl)-acetonitrile 2-Phenylmethansulfonyl-benzothiazol 1,3-benzothiazol-2-yl benzyl sulfone benzothiazol-2-yl-(2-chloro-pyrimidin-4-yl)-acetonitrile 2-<(phenylmethyl)sulfonyl>benzothiazole 2-(benzylsulfonyl)benzothiazole benzothiazol-2-benzyl sulfone 2-(benzylsulfonyl)benzo[d]thiazole |
| Description | JNK-IN-13 (compound 1) is a potent and selective JNK inhibitor with IC50s of 290 nM and 500 nM for JNK3 and JNK2, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
JNK2:500 nM (IC50) JNK3:290 nM (IC50) |
| References |
[1]. Serge Halazy, et al. Benzazole derivatives and their use as JNK modulators. EP1110957A1. |
| Molecular Formula | C13H7ClN4S |
|---|---|
| Molecular Weight | 286.74 |
| Exact Mass | 286.00800 |
| PSA | 90.70000 |
| LogP | 3.39518 |
|
~84%
345986-38-1 |
| Literature: ARES TRADING S.A. Patent: US2008/51397 A1, 2008 ; Location in patent: Page/Page column 21 ; |
| Precursor 2 | |
|---|---|
| DownStream 0 | |