136199-02-5
136199-02-5 structure
- Name: KW 3902
- Chemical Name: Rolofylline
- CAS Number: 136199-02-5
- Molecular Formula: C20H28N4O2
- Molecular Weight: 356.46200
- Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
- Create Date: 2017-01-28 07:31:12
- Modify Date: 2024-01-07 10:00:59
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Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment.Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450)[1].Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases[2].
| Name | Rolofylline |
|---|---|
| Synonyms |
KW 3902
MK-7418 1,3-Dnax |
| Description | Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment.Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450)[1].Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases[2]. |
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| Related Catalog | |
| References |
| Density | 1.262g/cm3 |
|---|---|
| Boiling Point | 578ºC at 760mmHg |
| Molecular Formula | C20H28N4O2 |
| Molecular Weight | 356.46200 |
| Flash Point | 303.4ºC |
| Exact Mass | 356.22100 |
| PSA | 72.68000 |
| LogP | 2.78400 |
| Vapour Pressure | 2.33E-13mmHg at 25°C |
| Index of Refraction | 1.605 |
| Hazard Statements | H413 |
|---|---|
| RIDADR | NONH for all modes of transport |
|
~99%
136199-02-5 |
| Literature: Kyowa Hakko Kogyo Co., Ltd. Patent: US5290782 A1, 1994 ; US 5290782 A |
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136199-02-5 |
| Literature: Synthesis, , # 7 p. 1123 - 1126 |
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136199-02-5 |
| Literature: Journal of Medicinal Chemistry, , vol. 35, # 5 p. 924 - 930 |
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136199-02-5 |
| Literature: Journal of Medicinal Chemistry, , vol. 35, # 5 p. 924 - 930 |
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136199-02-5 |
| Literature: Synthesis, , # 7 p. 1123 - 1126 |
| Precursor 4 | |
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| DownStream 0 | |