3564-73-6

3564-73-6 structure

Name: 10,11-Dihydrocarbamazepine
Chemical Name: 5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide
CAS Number: 3564-73-6
Molecular Formula: C₁₅H₁₄N₂O
Molecular Weight: 238.28
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-09-27 13:13:47
Modify Date: 2026-07-01 18:14:58
10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy[1].

Name	5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide
Synonyms	10,11-dihydro-5-carboxamido-5H-dibenz<b,f>azepine Dihydrocbamazine Cbamazine Related Compound A (30 mg) (10,11-dihydrocbamazine) 10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepin 10,11-Dihydro5H-dibenzo[b,f]azine-5-cboxamide 10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepine GP 26-301 10,11-DihydrocbaMazine CbaMazine Related CoMpound A Cbamazine Related Compound A (10,11-dihydrocbamazine) 10,11-Dihydro-5H-dibenzo[b,f]azine-5-cboxamide 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide 5,6-dihydrobenzo[b]benzazine-11-cboxamide MFCD00005072 10,11-Dihydro-5H-dibenz(b,f)azepine-5-carboxamide 10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide 5H-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE,10,11-DIHYDRO CbaMazine IMpurity-A 5H-Dibenz[b,f]azine-5-cboxaMide, 10,11-dihydro Oxcbazine Impurity 4 10,11-DIHYDROCARBAMAZEPINE Cbamazin-10,11-dihydro 100 μg/mL in Acetonitrile 10,11-Dihydrocbamazine (Cbamazine Impurity) EINECS 222-649-0 Oxcbazine Impurity RD Cbamazine impurity A CRS 10,11-Dihydro-5H-dibenzo[b,f]-azine-5-cboxamide (10,11-Dihydro-cbamazine) 1-Cyclopropyl-6,8-difluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-cboxylic acid HCl 10,11-Dihydrocarbamazepine,10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide 10,11-Dihydrocbamazine,10,11-Dihydro-5H-dibenz[b,f]azine-5-cboxamide Cbamazine Impurity A/ Cbamazine Related Compound A Cbamazine Impurity A (10,11-Dihydro Cbamazine) 10,11-Dihydro-5H-dibenzo[b,f]-azi f)azine-5-cboxamide,10,11-dihydro-5h-dibenz( GP / 10,11-Dihydrocbamazine/ 10,11-dihydro-5H-dibenzo[b,f]azine-5-cboxamide Cbamazine Impurity 1 Cbamazin-10.11-dihydro in Acetonitrile Cbamazin-10,11-dihydro Cbamazine Impurity 1(Cbamazine Impurity A） 10,11-DIHYDRO-5H-DIBENZ[B,F]AZINE-5-CBOXAMIDE Cbamazine Related Compound A (50 mg) (10,11-dihydrocbamazine)

Description	10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Oxcarbazepine is metabolized in the liver to its active metabolite, 10,11-Dihydrocarbamazepine. Oxcarbazepine is an antiepileptic drug (AED) used to treat partial seizures as a monotherapy or adjunctive therapy[1]. 10,11-Dihydrocarbamazepine may be used as a reference standard for the determination of 10,11-dihydrocarbamazepine in pharmaceutical formulations by liquid chromatography (LC)[1].
References	[1]. Courtney Hunek, et al. Measurement of 10,11-dihydro-10-hydroxy-carbamazepine in serum and plasma by high-performance liquid chromatography. Clin Chem Lab Med. 2008;46(10):1429-33.

Density	1.2±0.1 g/cm3
Boiling Point	394.5±52.0 °C at 760 mmHg
Melting Point	205-210ºC
Molecular Formula	C₁₅H₁₄N₂O
Molecular Weight	238.28
Flash Point	192.4±30.7 °C
Exact Mass	238.110611
PSA	46.33000
LogP	2.60
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.645
Storage condition	Refrigerator
Water Solubility	dichloromethane: soluble2.5%, clear, colorless \| Soluble in dichloromethane. Insoluble in water.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HN8300000

CHEMICAL NAME :: 5H-Dibenz(b,f)azepine-5-carboxamide, 10,11-dihydro-

CAS REGISTRY NUMBER :: 3564-73-6

BEILSTEIN REFERENCE NO. :: 0196969

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H14-N2-O

MOLECULAR WEIGHT :: 238.31

WISWESSER LINE NOTATION :: T C676 BN&T&J BVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,88,1964

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H317-H334
Precautionary Statements	P261-P280-P342 + P311
Hazard Codes	Xn
Risk Phrases	22-42/43
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	HN8300000
HS Code	2933990090

33948-19-5

~84%

3564-73-6

Literature: Shamshin, V. P.; Voronin, V. G.; Borisov, M. M.; Mufazalova, T. P. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 6 p. 443 - 448 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 6 p. 711 - 716

298-46-4

~85%

3564-73-6

Literature: Dunnbier; Jugelt Pharmazie, 1991 , vol. 46, # 7 p. 512 - 517

494-19-9

3564-73-6

Literature: Pharmaceutical Chemistry Journal, , vol. 21, # 6 p. 443 - 448 Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 6 p. 711 - 716

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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