1003566-93-5

1003566-93-5 structure

Name: AZD-4818
Chemical Name: 2-[2-chloro-5-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-(methylcarbamoyl)phenoxy]-2-methylpropanoic acid
CAS Number: 1003566-93-5
Molecular Formula: C₂₇H₃₂Cl₂N₂O₇
Molecular Weight: 567.45800
Catalog: Signaling Pathways GPCR/G Protein CCR
Create Date: 2017-11-28 17:52:01
Modify Date: 2026-07-08 19:25:21
AZD-4818 is a potent antagonist of chemokine CCR1. AZD-4818 can be used for the treatment of chronic obstructive pulmonary disease (COPD) [1].

Name	2-[2-chloro-5-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-(methylcarbamoyl)phenoxy]-2-methylpropanoic acid
Synonyms	2-{2-chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid form B CCR1 antagonist 2-{2-chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid form C 2-{2-chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid 2-{2-chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid form F 2-{2-chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid form G 2-{2-chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid form D chemokine,COPD,AZD-4818,AZD4818,CCR1,inhibit,Inhibitor,CCR,AZD 4818,chronic obstructive pulmony disease,CC chemokine rector AZD-4818, 10 mM in DMSO Propanoic acid, 2-[2-chloro-5-[(2S)-3-(5-chlorospiro[benzofuran-2(3H),4'-piperidin]-1'-yl)-2-hydroxypropoxy]-4-[(methylamino)carbonyl]phenoxy]-2-methyl UNII-S5UP6P540K 2-{2-chloro-5-[(2S)-3-{5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl}-2-hydroxypropoxy]-4-(methylcbamoyl)phenoxy}-2-methylpropanoic acid 2-{2-chloro-5-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid form A

Description	AZD-4818 is a potent antagonist of chemokine CCR1. AZD-4818 can be used for the treatment of chronic obstructive pulmonary disease (COPD) [1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Research Areas >> Endocrinology Signaling Pathways >> Immunology/Inflammation >> CCR Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	CCR1[1]
References	[1]. Norman P. AZD-4818, a chemokine CCR1 antagonist: WO2008103126 and WO2009011653. Expert Opin Ther Pat. 2009;19(11):1629-1633.

Molecular Formula	C₂₇H₃₂Cl₂N₂O₇
Molecular Weight	567.45800
Exact Mass	566.15900
PSA	121.05000
LogP	4.31710

1003567-28-9

~84%

1003566-93-5

Literature: ASTRAZENECA AB Patent: WO2009/11653 A1, 2009 ; Location in patent: Page/Page column 12; 25-27; 27 ; WO 2009/011653 A1

Precursor 1
1003567-28-9
DownStream 0

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