110101-67-2

110101-67-2 structure

Name: tirilazad
Chemical Name: (8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one,methanesulfonic acid
CAS Number: 110101-67-2
Molecular Formula: C₃₉H₅₆N₆O₅S
Molecular Weight: 720.96400
Catalog: Research Areas Infection
Create Date: 2016-02-24 11:46:33
Modify Date: 2024-10-02 18:23:36
Tirilazad mesylate (U 74006F) is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad mesylate can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad mesylate has antiviral activities against nCoV. Tirilazad mesylate is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].

Name	(8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one,methanesulfonic acid
Synonyms	[14C]-Tirilazad mesylate Freedox Tirilazad mesilate (JAN) UNII-19B418DV39 Freedox (TN) Tirilazad mesylate

Description	Tirilazad mesylate (U 74006F) is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad mesylate can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad mesylate has antiviral activities against nCoV. Tirilazad mesylate is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].
Related Catalog	Research Areas >> Infection Research Areas >> Neurological Disease
References	[1]. Bath PM, et al. Tirilazad for acute ischaemic stroke. Cochrane Database Syst Rev. 2001;(4):CD002087. [2]. Zhang S, et al. Tirilazad for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD006778. [3]. Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee. Stroke. 2000 Sep;31(9):2257-65.