1127498-03-6

1127498-03-6 structure

Name: JNJ-40411813
Chemical Name: 1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one
CAS Number: 1127498-03-6
Molecular Formula: C₂₀H₂₅ClN₂O
Molecular Weight: 344.87800
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2018-08-01 13:47:21
Modify Date: 2024-01-05 17:59:18
JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.IC50 value: 147 nM(EC50)Target: mGlu2RJNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity. JNJ-40411813 has been investigated in the clinic for schizophrenia and anxious depression disorders.

Name	1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one
Synonyms	1'-butyl-3'-chloro-4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']bipyridinyl-2'-one JNJ-40411813

Description	JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.IC50 value: 147 nM(EC50)Target: mGlu2RJNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity. JNJ-40411813 has been investigated in the clinic for schizophrenia and anxious depression disorders.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
References	[1]. Cid JM, et al. Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor. J Med Chem. 2014 Aug 14;57(15):6495-512.