118988-04-8

118988-04-8 structure

Name: Hydroxy-PEG3-ethyl acetate
Chemical Name: ethyl 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]acetate
CAS Number: 118988-04-8
Molecular Formula: C₁₀H₂₀O₆
Molecular Weight: 236.26200
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-10-03 20:48:32
Modify Date: 2024-01-09 18:25:24
Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	ethyl 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]acetate

Description	Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562